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Article Abstract
Objective: Upon exposure, persistent organic pollutants (POPs) accumulate in the body. One-time point measurement of POPs plasma concentrations can reflect body burden. This study aimed to assess whether maternal factors including age, breastfeeding, and weight, influence changes in plasma concentrations of POPs in women during critical periods of physical changes from pregnancy to 15-60 months after delivery.
Methods: Ninety-nine self-identified Hispanic women who were diagnosed with gestational diabetes mellitus (GDM) and originally enrolled in the GDM cohort study in 1993-1995 were included in this study. Plasma concentrations of 21 polychlorinated biphenyls (PCBs), 7 organochlorine pesticides (OCPs), 5 polybrominated diphenyl ethers (PBDEs), 2,2',4,4',5,5'-hexabromobiphenyl (BB153), and 6 per- and polyfluoroalkyl substances (PFAS) were quantified in archived samples collected in the 3rd trimester of pregnancy and post-delivery (81.8 % were from 15 months after delivery, the rest were from 30-60 months post-delivery). Multivariable linear regression was used to analyze associations of maternal factors such as weight change, age and breastfeeding status after delivery with changes in POPs concentrations from 3rd trimester of pregnancy to the post-delivery visit.
Results: From pregnancy to post-delivery period, plasma concentrations of 4 PBDEs and 6 PFAS significantly increased, while those of 20 PCBs, all OCPs and BB153 significantly decreased (all p-values < 0.05). Additionally, older age and breastfeeding after delivery were significantly associated with greater reduction in concentrations of PCBs, OCPs, and BB153 from pregnancy to the post-delivery period, whereas weight loss was associated with a smaller reduction in these POPs (all p-values < 0.05). Post-delivery weight gain was associated with greater elevation in concentrations of 2-(N-methylperfluorooctane sulfonamido) acetate and branched isomers of perfluorooctane sulfonate.
Conclusion: Concentrations of PCBs, OCPs, and BB153 declined more in older women and those who breastfed their newborns, whereas the decline was smaller among women who lost more weight after delivery.
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| http://dx.doi.org/10.1016/j.envint.2025.109723 | DOI Listing |
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