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Global water scarcity drives the need for sustainable water management. Non-potable greywater (GW) reuse offers a viable strategy to reduce urban water demand. However, potential public health risks associated with exposure to pathogens in GW necessitate careful consideration. The World Health Organization (WHO) has established a benchmark of 1×10 Disability-Adjusted Life Years (DALYs) per person per year (PPPY) for water-related health risks. This study develops and employs a stochastic Quantitative Microbial Risk Assessment (QMRA) model to evaluate the annual health risks associated with exposure to four bacterial pathogens in GW across eight exposure routes. Results indicate that exposure to raw GW presents an annual probability of illness of 1 × 10 PPPY. Conversely, the use of treated GW significantly reduces the illness probability to 3.9 × 10 PPPY, and the use of disinfected GW further decreases the risk to 7.1 × 10 PPPY, an order of magnitude lower than the WHO's acceptable risk level. The findings indicate that the use of treated-and-disinfected GW, when managed with appropriate precautions, can maintain health risks within the tolerable limits defined by the WHO. This study provides a robust risk assessment framework that can inform the sustainable implementation of hybrid urban water systems.
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http://dx.doi.org/10.2166/wst.2025.115 | DOI Listing |
Anal Methods
September 2025
Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, P. R. China.
Aflatoxin B1 (AFB1) is one of the most toxic mycotoxins that pose great health threats to humans. Herein, an aptasensor-based fluorescent signal amplification strategy is developed for the detection of AFB1. Initially, the AFB1 aptamers labelled with carboxyfluorescein (FAM) are adsorbed onto graphene oxide (GO), triggering energy transfer.
View Article and Find Full Text PDFProtein Cell
August 2025
Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200433, China.
Cardiovascular disease (CVD) research is hindered by limited comprehensive analyses of plasma proteome across disease subtypes. Here, we systematically investigated the associations between plasma proteins and cardiovascular outcomes in 53,026 UK Biobank participants over a 14-year follow-up. Association analyses identified 3,089 significant associations involving 892 unique protein analytes across 13 CVD outcomes.
View Article and Find Full Text PDFJ Investig Allergol Clin Immunol
September 2025
Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Background And Objectives: Pollen-food allergy syndrome (PFAS) is a frequent comorbidity in individuals with hay fever. Identifying risk factors and allergen clusters can aid targeted interventions and management strategies. Objective: This study characterizes PFAS in patients with hay fever and identifies associated risk factors using the mobile health platform, AllerSearch.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Department of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Cognitive impairment and dementia, including Alzheimer's disease (AD), pose a global health crisis, necessitating non-invasive biomarkers for early detection. This review highlights the retina, an accessible extension of the central nervous system (CNS), as a window to cerebral pathology through structural, functional, and molecular alterations. By synthesizing interdisciplinary evidence, we identify retinal biomarkers as promising tools for early diagnosis and risk stratification.
View Article and Find Full Text PDFGlob Chang Biol
September 2025
European Centre for Medium-Range Weather Forecast (ECMWF), Reading, UK.
The catastrophic Los Angeles Fires of January 2025 underscore the urgent need to understand the complex interplay between hydroclimatic variability and wildfire behavior. This study investigates how sequential wet and dry periods, hydroclimatic rebound events, create compounding environmental conditions that culminate in extreme fire events. Our results show that a cascade of moisture anomalies, from the atmosphere to vegetation health, precedes these fires by around 6-27 months.
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