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The conventional Capon beamforming algorithm can achieve a high gain in the direction of desired signals and zero-trapping in the direction of interfering signals, providing a high output signal-to-interference-plus-noise ratio (SINR). However, when the steering vector of the desired signal is mismatched, the performance of the Capon beamforming algorithm degrades. In addressing this challenge, the present research introduces a refined algorithm. The core of the proposed robust Capon beamforming technique lies in leveraging the orthogonality between the steering vector and the noise space, the estimated expected signal steering vector is corrected. Based on this feature, the proposed algorithm meticulously optimizes the predicted steering vector of the desired signal, which can mitigate the problem of performance degradation caused by the mismatch in the steering vector. Moreover, the covariance matrix is corrected using the desired signal elimination method, which can overcome the problem of signal self-cancelation. Furthermore, through the optimization process, the proposed algorithm can maintain high robustness in complex environments and under the condition of different input signals, its beam pattern performance is more excellent. The results of simulation experiments show that the proposed algorithm demonstrates greater robustness compared to the currently available algorithms, can achieve a higher output SINR, and is insensitive to steering vector mismatch.
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http://dx.doi.org/10.3390/s25154570 | DOI Listing |
J Neural Eng
September 2025
Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales - LEICI (UNLP-CONICET), Facultad de Ingeniería, Universidad Nacional de la Plata, Calle 48 y 116, La Plata, Buenos Aires Province, 1900, ARGENTINA.
Objective: In temporal interference (TI) transcranial electrical stimulation (tES), an emerging brain stimulation technique, the interference of two high-frequency currents with a small frequency difference is used to target specific brain regions with better focality than in standard tES. While the magnitude of the modulation depth has been previously investigated, an explicit formula for the direction in which this modulation is maximized has been lacking. This work provides a novel closed-form analytical expression for the orientation of maximum modulation depth in TI tES.
View Article and Find Full Text PDFbioRxiv
August 2025
Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, 15217, US.
Codon sequence design is crucial for generating mRNA sequences with desired functional properties for tasks such as creating novel mRNA vaccines or gene editing therapies. Yet existing methods lack flexibility and controllability to adapt to various design objectives. We propose a novel framework, ARCADE, that enables flexible control over generated codon sequences.
View Article and Find Full Text PDFNat Rev Chem
August 2025
Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
The past decade has witnessed remarkable advancements in autonomous systems, such as automobiles that are evolving from traditional vehicles to ones capable of navigating complex environments without human intervention. Similarly, the rise of self-driving laboratories (SDLs), which leverage robotics and artificial intelligence to accelerate discovery, is driving a paradigm shift in scientific research. As SDLs evolve to expand the scope of chemical processes that can be performed, it is essential to bring safety to the forefront to ensure that the necessary safeguards are in place to mitigate against potential accidents that range from near-misses to catastrophic failures.
View Article and Find Full Text PDFSensors (Basel)
July 2025
College of Information Engineering, Inner Mongolia University of Technology, Hohhot 010080, China.
The conventional Capon beamforming algorithm can achieve a high gain in the direction of desired signals and zero-trapping in the direction of interfering signals, providing a high output signal-to-interference-plus-noise ratio (SINR). However, when the steering vector of the desired signal is mismatched, the performance of the Capon beamforming algorithm degrades. In addressing this challenge, the present research introduces a refined algorithm.
View Article and Find Full Text PDFLancet
August 2025
Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China. Electronic address: