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Time-of-flight (ToF) sensors with single-photon avalanche diodes (SPADs) estimate depth by accumulating a histogram of photon return times, which discards the timing information required to measure depth dynamics, such as vibrations or transient motions. We introduce a method that transforms a direct ToF sensor into a depth frequency analyzer capable of measuring high-frequency motion and transient events using only lightweight, on-sensor computations. By replacing conventional discrete Fourier transforms (DFTs) with one-bit probing sinusoids generated via oversampled sigma-delta modulation, we enable in-pixel frequency analysis without multipliers or floating-point operations. We extend the lightweight analysis of depth dynamics to Haar wavelets for time-localized detection of brief, non-repetitive depth changes. We validate our approach through simulation and hardware experiments, showing that it achieves noise performance approaching that of full-resolution DFTs, detects sub-millimeter motions above 6 kHz, and localizes millisecond-scale transients. Using a laboratory ToF setup, we demonstrate applications in oscillatory motion analysis and depth edge detection. This work has the potential to enable a new class of compact, motion-aware ToF sensors for embedded deployment in industrial predictive maintenance, structural health monitoring, robotic perception, and dynamic scene understanding.
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http://dx.doi.org/10.1109/TPAMI.2025.3598593 | DOI Listing |
J Am Chem Soc
September 2025
College of Chemistry and Molecular Sciences, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430072, P. R. China.
The in-depth integration of gene regulation with protein modulation can enhance cellular information processing, yet it is significantly constrained by ineffective and complex protein-to-gene transduction strategies. Herein, we developed a simple protease-guided autocatalytic gene silencing platform named iPAD (intelligent peptide-programmed deoxyribonuclease) that converts the protease recognition events into versatile DNA readout signals by rationally designing a native protease-responsive cationic peptide (PP) to efficiently modulate the DNAzyme (Dz) activity. Without requiring additional chemical modifications, the multifunctional PP regulator consists simply of one cell-specific targeting peptide segment and two cationic peptide segments isolated by one protease-specific peptide substrate.
View Article and Find Full Text PDFComput Methods Biomech Biomed Engin
September 2025
Center for Medical Metrology, National institute of metrology, Beijing, China.
Geometric changes in the sigmoid sinus diverticulum (SSD) can alter its hemodynamic - a primary factor contributing to pulsatile tinnitus (PT). However, not all SSD cases lead to clinical PT symptoms. This study aims to investigate the influence of the diameter of the diverticulum (EDD) on the hemodynamics of the sigmoid sinus in PT.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
State Key Laboratory of Materials for Integrated Circuits, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Selenium, as an important semiconductor material, exhibits significant potential for understanding lattice dynamics and thermoelectric applications through its thermal transport properties. Conventional empirical potentials are often unable to accurately describe the phonon transport properties of selenium crystals, which limits in-depth understanding of their thermal conduction mechanisms. To address this issue, this study developed a high-precision machine learning potential (MLP), with training datasets generated molecular dynamics simulations.
View Article and Find Full Text PDFGeohistorical events are among the most important factors determining population genetic structure. The Sea of Japan is an intriguing area because of its connection to neighboring seas via shallow straits (< 140 m deep) and the occurrence of deep-water anoxic events during glacial periods. Despite repeated anoxic events, species with low dispersal capabilities have been reported at depths deeper than the straits in both the Sea of Japan and the Pacific Ocean.
View Article and Find Full Text PDFRisk Manag Healthc Policy
September 2025
Center for Geriatric Healthcare Services and Health Education, Rizhao, People's Republic of China.
Background: Older adults in rural China bear a significant proportion of their healthcare expenses through out-of-pocket payments, resulting in a considerable financial burden on their families.
Objective: This study aimed to explore the key factors influencing adult children's involvement in financing healthcare expenses for their elderly parents in rural China.
Methods: Data were collected by in-depth interviews using a semi-structured interview guide approved by all researchers.