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Fetal arrhythmias account for 10-20% of all outpatient consultations in specialized fetal medicine centers. Furthermore, it is evident that tachyarrhythmias account for 8% of all such arrhythmias. Most arrhythmias are benign and easy to manage, but certain tachyarrhythmias require close monitoring due to the risk of decompensation, progression to heart failure with hydrops, and potential fetal death. The aim of this study was to describe the most common fetal tachycardias and their intrauterine management. Using fetal ultrasound/echocardiography, clinicians can assess the heart rate (HR), fetal heart rhythm, and determine rhythm patterns. Differentiating the type of fetal tachyarrhythmia is crucial, as certain antiarrhythmic drugs are more effective for specific arrhythmias. Despite advances in diagnosis and treatment, studies reveal limited numbers of patients, and a wide variety of treatments based on local experience and available resources. The potential of fetal treatment to improve prognosis in both fetal and postnatal life has been well demonstrated. There are several treatment options for fetal tachyarrhythmias, with the most effective medication selected based on the healthcare team's experience and practical treatment considerations. Transplacental therapy is the most widely used route for administering antiarrhythmic drugs in utero. In general, studies have been demonstrated the superior efficacy of flecainide and sotalol in comparison to digoxin in the treatment of fetal supraventricular tachycardia (SVT), with or without fetal edema. Flecainide can be used in combination with digoxin to treat SVT and hydrops in fetuses. For sustained ventricular tachycardia (VT), first-line treatment is maternal intravenous magnesium when fetal HR exceeds 200 bpm. In addition, it is important to keep in mind that frequency control is the treatment option for fetuses in which reversal to sinus rhythm has not been successful and pulmonary immaturity is present.
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http://dx.doi.org/10.21037/tp-2025-67 | DOI Listing |
J Crohns Colitis
September 2025
Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Background & Aims: Pregnancy can be a complex and risk-filled event for women with inflammatory bowel disease (IBD). High-quality studies in this population are lacking, with limited data on medications approved to treat IBD during pregnancy. For patients, limited knowledge surrounding pregnancy impacts pregnancy rates, medication adherence, and outcomes.
View Article and Find Full Text PDFAcad Radiol
September 2025
Associate Professor of Radiology, University of Pennsylvania, Philadelphia, PA 19146 (S.J.). Electronic address:
Rationale And Objectives: To understand how an imperfect surrogate can lead to defensive medicine.
Materials And Methods: Historical analysis was performed on electronic fetal monitoring.
Results: Electronic Fetal Monitoring is an example of a flawed surrogate.
Gait Posture
September 2025
Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RN115, Boston, MA 02215, USA.
Mol Cell Endocrinol
September 2025
Department of Epidemiology, University of Michigan, Ann Arbor, USA. Electronic address:
Steroid hormones are integral to pregnancy and fetal development, regulating processes such as metabolism, inflammation, and immune responses. Excessive prenatal steroid exposure, through lifestyle choices or environmental chemicals, can lead to metabolic dysfunctions in offspring. The research focuses on how exposure to testosterone (T) and bisphenol A (BPA) affects the liver's DNA methylome, a key component of the epigenome influencing long-term health.
View Article and Find Full Text PDFResuscitation
September 2025
Department of Pediatrics, Division of Neonatology, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Division of Neonatology, 2(nd) Floor, Main Building, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Aim: Flow disruptions (FDs) are deviations in the progression of care that compromise safety and efficiency of a specific process. Neonatal intubation is a life-saving high-risk procedure required for delivery room (DR) management of neonates with moderate to severe congenital diaphragmatic hernia (CDH). This study evaluated FDs during DR intubation of neonates with CDH and their association with process and outcome measures.
View Article and Find Full Text PDF