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The context for our paper comes from the neurophenomenology (NPh) research programme initiated by Francisco Varela at the end of the 1990s. Varela's working hypothesis was that, to be successful, a consciousness research programme must progress by relating first-person phenomenological accounts of the structure of experience and their third-person counterparts in neuroscience through "mutual constraints". Leveraging Bayesian mechanics, in particular deep parametric active inference, we demonstrate the potential for epistemically advantageous mutual constraints between phenomenological, computational, behavioural, and physiological vocabularies. Specifically, the dual information geometry of Bayesian mechanics serves to establish, under certain conditions, generative passage between lived experience and its physiological instantiation. This paper argues for the epistemological necessity of such a passage and the inclusion of trained reflective awareness in neurophenomenological empirical approaches. In particular, it showcases incremental explanatory gains for the scientist that arise from incorporating the participants' epistemic insights, shifting the focus from the contents of experience (i.e. what a subject experiences in a given experimental set-up) to the how of experience (i.e. the activities of consciousness that allow for a meaningful world to appear to us as such in lived experience). The explanatory power of the resulting 'meta-Bayesian' framework, deep computational NPh, arises from the disciplined circulation between first and third-person perspectives enabled by the formalism of deep parametric active inference, where parametric depth refers to a property of generative models that can form beliefs about the parameters of their own modelling process. Hence, this computational formalism contributes to understanding consciousness by bridging phenomenological descriptions and physiological instantiations, whilst also highlighting the significance of trained first-person investigation in experimental protocols.
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http://dx.doi.org/10.1093/nc/niaf016 | DOI Listing |
BMC Oral Health
September 2025
Oral and Maxillofacial Radiology Department, Cairo university, Cairo, Egypt.
Aim: The purpose of this study was to assess the accuracy of a customized deep learning model based on CNN and U-Net for detecting and segmenting the second mesiobuccal canal (MB2) of maxillary first molar teeth on cone beam computed tomography (CBCT) scans.
Methodology: CBCT scans of 37 patients were imported into 3D slicer software to crop and segment the canals of the mesiobuccal (MB) root of the maxillary first molar. The annotated data were divided into two groups: 80% for training and validation and 20% for testing.
BMC Musculoskelet Disord
September 2025
Department of Clinical Sciences at Danderyds Hospital, Department of Orthopedic Surgery, Karolinska Institutet, Stockholm, 182 88, Sweden.
Background: This study evaluates the accuracy of an Artificial Intelligence (AI) system, specifically a convolutional neural network (CNN), in classifying elbow fractures using the detailed 2018 AO/OTA fracture classification system.
Methods: A retrospective analysis of 5,367 radiograph exams visualizing the elbow from adult patients (2002-2016) was conducted using a deep neural network. Radiographs were manually categorized according to the 2018 AO/OTA system by orthopedic surgeons.
Nat Microbiol
September 2025
Joan and Sanford I. Weill Department of Medicine, Gastroenterology and Hepatology Division, Weill Cornell Medicine, New York, NY, USA.
Microbial influence on cancer development and therapeutic response is a growing area of cancer research. Although it is known that microorganisms can colonize certain tissues and contribute to tumour initiation, the use of deep sequencing technologies and computational pipelines has led to reports of multi-kingdom microbial communities in a growing list of cancer types. This has prompted discussions on the role and scope of microbial presence in cancer, while raising the possibility of microbiome-based diagnostic, prognostic and therapeutic tools.
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September 2025
Fukushima Renewable Energy Institute, Koriyama, Japan.
Ultra-fast charging stations (UFCS) present a significant challenge due to their high power demand and reliance on grid electricity. This paper proposes an optimization framework that integrates deep learning-based solar forecasting with a Genetic Algorithm (GA) for optimal sizing of photovoltaic (PV) and battery energy storage systems (BESS). A Gated Recurrent Unit (GRU) model is employed to forecast PV output, while the GA maximizes the Net Present Value (NPV) by selecting optimal PV and BESS sizes tailored to weekday and weekend demand profiles.
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September 2025
Department of Communications and Electronics, Delta University for Science and Technology, Mansoura, Egypt.