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Tm-doped YLF crystals with different doping concentrations are grown and investigated for their suitability for continuous-wave laser operation on the H→F transition around 1.5 µm. Our spectroscopic investigations reveal the emission, absorption, and gain cross sections as well as the concentration-dependent lifetime of the relevant energy levels. Self-termination of the laser is circumvented in a cascade laser scheme H→F→H for efficient depopulation of the long-living lower laser level F. In this way, simultaneous laser operation at 1509 nm and 1923 nm with slope efficiencies of 44% and 35% and pump-power-limited output powers of 590 mW and 670 mW are obtained under 781-nm Ti:sapphire laser pumping, respectively.
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http://dx.doi.org/10.1364/OE.559428 | DOI Listing |
ACS Appl Mater Interfaces
September 2025
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, No.55 West Zhongshan Avenue, Tianhe District, Guangzhou 510631, Guangdong, China.
While reactive oxygen species (ROS)-dependent chemodynamic therapy (CDT) and photodynamic therapy (PDT) hold promise for cancer treatment, their efficacy remains constrained by tumor microenvironment (TME) barriers: glutathione (GSH) overexpression, insufficient HO supply, and hypoxia. To address these limitations, we engineered a Trojan horse-inspired MnO-shelled CaO nanoreactor (CaO/MnO-Ce6-PEG) by employing a sequential TME reprogramming strategy, triggering a cascading ROS storm for enhanced CDT and PDT. The outer MnO layer first depletes GSH through redox conversion, exposing the CaO core hydrolysis, and subsequently providing HO for CDT and O for ameliorating hypoxia to boost Ce6-mediated PDT.
View Article and Find Full Text PDFJ Colloid Interface Sci
September 2025
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China; Henan International Joint Laboratory of Smart Molecules and Identification and Diagnostic Functions, Henan Normal University, Xinxiang, Henan 453007, China. Electronic address:
Carbon monoxide (CO) has demonstrated significant potential in tumor therapy. However, the uncontrolled release of CO and single-modality therapy often fail to achieve the desired therapeutic outcomes. To address the above deficiencies, mesoporous silica nanoparticles containing tetrasulfide bonds (TMSNs) were constructed as intelligent nanocarriers to co-deliver a mitochondria-targeting photosensitizer (Au-TPP) and a photodynamically activated CO-releasing molecule (FeCO), enabling the synergistic combination of photodynamic therapy (PDT) and CO therapy.
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Chemistry, Stanford University, Stanford CA 94305, USA.
The detection of drug-target interactions in live cells enables analysis of therapeutic compounds in a native cellular environment. Recent advances in spectroscopy and molecular biology have facilitated the development of genetically encoded vibrational probes like nitriles that can sensitively report on molecular interactions. Nitriles are powerful tools for measuring electrostatic environments within condensed media like proteins, but such measurements in live cells have been hindered by low signal-to-noise ratios.
View Article and Find Full Text PDFACS Omega
August 2025
Radioisotope Science and Technology Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37830, United States.
A method was developed to sample molten salts by sparging to generate and transport aerosols to an isolated instrument for compositional analysis by laser-induced breakdown spectroscopy (LIBS). Real-time monitoring of molten salt composition is critical to developing molten salt nuclear reactors, which offer enhanced safety and efficiency. In this article, the sparge sampling method is described and compared with sampling using a Collison nebulizer.
View Article and Find Full Text PDFSci Rep
September 2025
Department of Photonics, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan.
This paper characterizes the performance of 940 nm single-junction (1 J) and triple-junction (3 J) vertical-cavity surface-emitting laser (VCSEL) arrays, tested at room temperature under 1.8 ns pulsed current injection. By suppressing thermal effects, the slope efficiency (SE) of the 1 J VCSEL array reaches 1.
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