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Aberrations in minimalist optical imaging systems present significant challenges for achieving high-quality imaging. Traditional methods often rely on precise aberration models, while deep learning approaches typically do not incorporate prior knowledge and lack interpretability. To address these limitations, we introduce the deep attention Wiener network (DAWNet), a differentiable framework that combines deep learning with Wiener deconvolution. DAWNet begins by extracting deep features using a convolutional neural network (CNN). These features are segmented by the field of view (FOV) based on spatial degradation and processed through a Wiener deconvolution module. To minimize distinct boundaries between adjacent segments, we employ innovative sliding sampling and a weighting matrix, facilitating efficient and accurate aberration correction closely aligned with physical models. The processed image blocks then pass through a post-processing attention module for further aberration correction and feature fusion, ultimately reconstructing high-quality images. We validate the efficacy of DAWNet by designing and implementing a minimalist optical system with two lenses. Both simulation and experimental results demonstrate that DAWNet significantly improves aberration correction compared to other techniques.
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http://dx.doi.org/10.1364/AO.547094 | DOI Listing |
Mol Psychiatry
September 2025
Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 44115, USA.
Dysregulated spine morphology is a common feature in the pathology of many neurodevelopmental and neuropsychiatric disorders. Overabundant immature dendritic spines in the hippocampus are causally related to cognitive deficits of Fragile X syndrome (FXS), the most common form of heritable intellectual disability. Recent findings from us and others indicate autophagy plays important roles in synaptic stability and morphology, and autophagy is downregulated in FXS neurons.
View Article and Find Full Text PDFGenes Dev
September 2025
Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA;
For neurons to establish the correct connections in animal nervous systems, interactions between cell adhesion molecules (CAMs), expressed presynaptically and postsynaptically, are thought to guide neurons to their targets. Here, we assess the role that affinity between two cognate CAMs-DIP-α and Dpr10-plays in establishing the leg neuromuscular system in If affinity decreases or, surprisingly, increases past certain thresholds, motor neuron (MN) terminal branches fail to be maintained. Live imaging during development shows that when affinities are aberrant, MN filopodia are unable to productively engage their muscle targets.
View Article and Find Full Text PDFLight Sci Appl
September 2025
Laboratory of Quantum Information, University of Science and Technology of China, 230026, Hefei, China.
Quantum imaging with spatially entangled photons offers advantages such as enhanced spatial resolution, robustness against noise, and counterintuitive phenomena, while a biphoton spatial aberration generally degrades its performance. Biphoton aberration correction has been achieved by using classical beams to detect the aberration source or scanning the correction phase on biphotons if the source is unreachable. Here, a new method named position-correlated biphoton Shack-Hartmann wavefront sensing is introduced, where the phase pattern added on photon pairs with a strong position correlation is reconstructed from their position centroid distribution at the back focal plane of a microlens array.
View Article and Find Full Text PDFIEEE Trans Med Imaging
September 2025
In ultrasound imaging, propagation of an acoustic wavefront through heterogeneous media causes phase aberrations that degrade the coherence of the reflected wavefront, leading to reduced image resolution and contrast. Adaptive imaging techniques attempt to correct this phase aberration and restore coherence, leading to improved focusing of the image. We propose an autofocusing paradigm for aberration correction in ultrasound imaging by fitting an acoustic velocity field to pressure measurements, via optimization of the common midpoint phase error (CMPE), using a straight-ray wave propagation model for beamforming in diffusely scattering media.
View Article and Find Full Text PDFJ Refract Surg
September 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Purpose: To evaluate axis-dependent visual and refractive outcomes of small incision lenticule extraction (SMILE) in patients with interocular astigmatic axis discordance.
Methods: Seventy-five patients (150 eyes) with interocular astigmatic axis discordance were included in the study. Based on interocular axis combinations, patients were stratified into three cohorts: with-the-rule (WTR)/against-the-rule (ATR) (n = 19), WTR/oblique astigmatism (OA) (n = 39), and ATR/OA (n = 17).