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http://dx.doi.org/10.1016/j.jcmgh.2025.101594 | DOI Listing |
Biotechnol J
September 2025
Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Mānoa, Honolulu, Hawai'i, USA.
CRISPR technologies are rapidly transforming agriculture by enabling precise and programmable modifications across a wide range of organisms. This review provides an overview of CRISPR applications in crops, livestock, aquaculture, and microbial systems, highlighting key advances in sustainable agriculture. In crops, CRISPR has accelerated the improvement of traits such as drought tolerance, nutrient efficiency, and pathogen resistance.
View Article and Find Full Text PDFHorm Metab Res
September 2025
Department of Obstetrics, Fujian Maternity and Child Health Hospital, Fuzhou, China.
The non-insulin-based metabolic score for insulin resistance (METS-IR) is a recently developed index aimed at being a practical and efficient alternative biomarker of insulin resistance (IR). This study aimed to investigate the association between METS-IR in euthyroid women in the first trimester of pregnancy and pregnancy outcomes. A total of 1810 participants who gave birth at Fujian Maternity and Child Health Hospital from November 2018 to November 2019 were included in this study.
View Article and Find Full Text PDFDiabetologia
September 2025
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Aims/hypothesis: Alpha cell dysregulation is an integral part of type 2 diabetes pathophysiology, increasing fasting as well as postprandial glucose concentrations. Alpha cell dysregulation occurs in tandem with the development of insulin resistance and changes in beta cell function. Our aim was to investigate, using mathematical modelling, the role of alpha cell dysregulation in beta cell compensatory insulin secretion and subsequent failure in the progression from normoglycaemia to type 2 diabetes defined by ADA criteria.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Obstetrics, Nantong University Affiliated Maternal and Child Health Hospital, Nantong, Jiangsu, China.
This study aimed to evaluate the association between a dietary education approach grounded in the transtheoretical model and cognitive load theory and glycemic control and pregnancy-related outcomes in patients diagnosed with gestational diabetes mellitus (GDM). A retrospective analysis was performed using clinical data from 126 pregnant women with GDM who received care at our hospital between September 2021 and September 2023. Participants were grouped based on the type of nursing intervention received: a control group that underwent standard care and an observation group that received an additional cognitive load-informed dietary education program based on transtheoretical model.
View Article and Find Full Text PDFIndian J Endocrinol Metab
July 2025
Department of Endocrinology, Indraprastha Apollo Hospitals, New Delhi, India.
The significance of hypoglycaemia during oral glucose tolerance tests (OGTT) in pregnancy is uncertain. This systematic review and meta-analysis (SRM) evaluated if hypoglycaemia during OGTT predicts feto-maternal outcomes. Electronic databases were searched for studies in pregnancy where an OGTT at 24-28 weeks was done and feto-maternal outcomes were documented.
View Article and Find Full Text PDF