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Article Abstract
Objective: To systematize data on the role of monocytes in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
Material And Methods: Forty-six scientific publications (1990-2024) on the role of monocytes in the pathogenesis of EAE and MS were analyzed.
Results: Monocytes have been found to play an essential role in both the occurrence and persistence of autoimmune neuroinflammation. They penetrate the central nervous system (CNS) through the blood-brain barrier, produce pro-inflammatory cytokines, differentiate into macrophages/dendritic cells, and activate CD4 T-cells. The change in both quantitative and functional characteristics of monocytes in MS is described.
Conclusion: Monocytes are involved in all stages of the immunopathogenesis of EAE and MS and largely mediate autoimmune demyelination in the CNS. Therefore, they can be considered a potential therapeutic target for MS.
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