[The role of monocytes in the immunopathogenesis of multiple sclerosis].

Objective: To systematize data on the role of monocytes in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).

Material And Methods: Forty-six scientific publications (1990-2024) on the role of monocytes in the pathogenesis of EAE and MS were analyzed.

Results: Monocytes have been found to play an essential role in both the occurrence and persistence of autoimmune neuroinflammation.

The role of neuroinflammation in schizophrenia: Focus on Th17 cells functions.

Schizophrenia is a severe mental disorder associated with behavioural, cognitive, and emotional impairments. There are several leading theories on schizophrenia etilology, including genetic, neurotransmitter (dopamine and GABA-glutamate are the leading ones), immunological (microglial, cytokine, kynurenine) and neurodevelopmental (neuro-ontogenetic and neurodegenerative) theories. Despite the fact that in recent decades, the greatest efforts have been directed towards testing and developing genetic and neurotransmitter (including dopamine) theories, the recent evidence suggests that immunological aspects, in particular neuroinflammation (cytokine hypothesis) may play an important role in schizophrenia.

[The role of dopamine receptors in the modulation of mononuclear phagocytes in multiple sclerosis].

Objective: To investigate the role of dopamine receptor DDR and DDR in the production of cytokines interleukin-6 (IL-6) and IL-1β by monocytes and macrophages in patients with relapsing-remitting multiple sclerosis (MS).

Material And Methods: Ten patients with relapsing-remitting MS and 10 healthy subjects were examined. The level of IL-6 and IL-1β production was assessed in culture supernatants obtained from CD14 monocytes or macrophages stimulated with interferon-γ (IFN-γ) and lipopolysaccharide (LPS).

[Features of the Reperfusion Therapy for ST-Segment Elevation Myocardial Infarction According to the Russian Registry of Acute Myocardial Infarction - REGION-IM].

Aim: Based on data from the Russian REGION-IM registry, to study the features of reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI) in real-life clinical practice.

Material And Methods: REGION-IM is a multicenter prospective observational study. The observational period is divided into 3 stages: during the stay in the hospital and at 6 and 12 months after inclusion in the registry.

[The influence of fluoxetine on neuroimmune interaction in multiple sclerosis].

Objective: To study the effect of fluoxetine on Th17- and Th1-immune response, which plays an important role in the pathogenesis of multiple sclerosis (MS).

Material And Methods: Ten patients with relapsing-remitting MS and ten healthy subjects were examined. The functions of Th17- and Th1-immune responses were assessed by the production of cytokines interleukin-17 (IL-17) and interferon-gamma (IFN-γ) by CD4 T cells stimulated with macrophages or microbeads coated with anti-CD3 and anti-CD28-antibodies.