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http://dx.doi.org/10.1007/s00266-025-05098-y | DOI Listing |
Acta Anaesthesiol Scand
October 2025
Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.
Background: Multiple organ dysfunction syndrome (MODS) in critical illness involves dysregulated immune and inflammatory responses, endotheliopathy, and coagulation activation. We investigated how three types of endotheliopathy biomarkers relate to pro- and anti-inflammatory responses and clinical outcomes in intensive care unit (ICU) patients.
Methods: In this secondary, explorative analysis of a prospective single-centre cohort (n = 459), we assessed associations between endotheliopathy biomarkers (syndecan-1, soluble thrombomodulin (sTM), platelet endothelial cell adhesion molecule-1 (PECAM-1)) and inflammatory biomarkers (pro-inflammatory: IFN-ϒ, IL-1β, IL-2, IL-6, IL-8, IL-12p70, TNF-α; anti-inflammatory: IL-4, IL-10, IL-13) at ICU admission using linear regression.
Hum Reprod
September 2025
Department of Philosophy and Moral Sciences, Bioethics Institute Ghent, Ghent University, Ghent, Belgium.
Study Question: What information does an international group of professionals and egg donors consider relevant and morally necessary for prospective egg donors to provide valid informed consent?
Summary Answer: Participants considered 80% of all concrete information items (CIIs) to be relevant (e.g. all legal aspects) and 67% to be morally necessary.
JMIR Form Res
September 2025
Department of Orthopedics, The First People's Hospital of Guannan: Lianyun, Lianyungang, China.
Background: Adolescence is a critical period for lifelong health, which makes access to accurate and comprehensive sexuality education essential. As video platforms become a primary source of information for adolescents, the quality of their content significantly impacts their physical and mental health.
Objective: This study aimed to evaluate the quality, reliability, understandability, and actionability of adolescent sexuality education videos on major Chinese platforms (Bilibili, TikTok or Douyin, and Kwai), analyze associated user comment sentiment and topics, identify predictors of quality and reliability, and provide recommendations.
NeuroRehabilitation
September 2025
Sindh Medical College, Jinnah Sindh Medical University, Karachi, Pakistan.
Front Pharmacol
August 2025
Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, China.