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Following the global increase in atherosclerotic cardiovascular diseases, the demand for the effective identification of high-risk factors that lead to atherosclerotic plaque rupture and the search for new therapeutic targets has also increased. Neovascularization within plaques is widely recognized as an important indicator of plaque vulnerability. Thus, the timely detection of neovascularization within plaques and early intervention treatment can help reduce the potential adverse cardiovascular events caused by plaque rupture. This article introduces the formation mechanism, clinical significance, detection techniques, and prevention strategies for neovascularizing atherosclerotic plaques.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326462 | PMC |
http://dx.doi.org/10.31083/RCM36468 | DOI Listing |
Kaohsiung J Med Sci
September 2025
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Rosuvastatin (RVS) is an HMG-CoA reductase inhibitor with lipid-lowering properties. This study aims to investigate the role of RVS in plaque formation in atherosclerosis (AS) and its functional mechanism. ApoE mice were fed a high-fat diet to generate a mouse model of AS.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Growing evidence indicates that coronary plaque instability is an independent risk factor for adverse coronary events, yet current optical coherence tomography (OCT) assessment of high-risk plaque characteristics (HRPC) relies largely on qualitative interpretation. The index of plaque attenuation (IPA) is a quantitative OCT-based metric that may provide a more objective evaluation. This retrospective observational diagnostic accuracy study assessed the performance of OCT-derived IPA for HRPC detection in patients with acute coronary syndrome or stable angina, using expert consensus qualitative OCT analysis as the reference standard.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Pernambuco Cardiac Emergency Hospital, University of Pernambuco (PROCAPE, UPE), Recife, Brazil.
Atherosclerosis is the most important etiology of acute myocardial infarction, which is considered an inflammatory disease with specific cellular and molecular responses. Recent research has linked hematological variables as biomarkers of the severity of coronary artery disease. Studies suggest that nucleated red blood cells (NRBCs), neutrophil to lymphocyte ratio (NLR), and mean platelet volume (MPV) may serve as components of a laboratory model or hematological scoring system for in-hospital surveillance.
View Article and Find Full Text PDFMater Today Bio
October 2025
Department of Pharmacy, First Affiliated Hospital, Shihezi University, Shihezi, 832008, China.
Modulating macrophage function is an effective strategy for treating atherosclerosis. Our previous research shows that tilianin (Til) effectively regulates macrophage polarization. This immune modulation positions Til as a promising plant-derived therapeutic agent with potential for atherosclerosis treatment and management.
View Article and Find Full Text PDFAtherosclerosis (AS) is a significant contributor to cardiovascular events. Recent studies have demonstrated that ferroptosis of foam cells is a significant driver of AS. Nevertheless, insights into the precise antiferroptosis therapies remain limited.
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