Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Parabolic flight serves as an important terrestrial analog to study acute physiological changes in microgravity without the need for space travel. During a parabolic flight, alternating hypergravity and microgravity phases, lasting up to 40 seconds, enable research into ophthalmic changes. In this review, we discuss the application of parabolic flight as a platform to study microgravity-related changes that might impact ophthalmology including intraocular pressure, intracranial pressure, choroidal blood flow, and modified eye movement patterns. We further highlight how these insights could aid our understanding of vestibulo-ocular reflexes and conditions such as Spaceflight Associated Neuro-ocular Syndrome (SANS). While the brief duration of microgravity exposure limits some applications, parabolic flight continues to provide a controlled environment for examining acute gravitational effects on eye health and evaluating many space medicine interventions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332269 | PMC |
| http://dx.doi.org/10.1016/j.lssr.2025.03.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
We have liftoff: A discovery study to use artificial intelligence to identify adaptative profiles for future space missions.
Physiol Rep
September 2025
Human Adaptation Institute, Marseille, France.
Long-duration space missions will challenge astronauts' adaptive capacities. Interoception and heart rate variability (HRV), reflecting parasympathetic activity, are increasingly recognized as predictors of adaptation and health. This study investigated whether artificial intelligence may predict adaptation profiles from interoceptive and HRV responses accross different space analogs.
View Article and Find Full Text PDFEvaluating the Suitability of Perfusion-Based PD Probes for Use in Altered Gravity Environments.
Biosensors (Basel)
July 2025
Harvard-MIT Division of Health Sciences and Technology (HST), Boston, MA 02139, USA.
Measurable changes in electrophysiology have been documented in spaceflight, creating a pathway for disease genesis and progression in astronauts. These electrophysiology changes can be measured using potential difference (PD). A probe to measure PD was developed and is used clinically on Earth; this probe relies on fluid perfusion to establish an electrical connection to make PD measurements.
View Article and Find Full Text PDFParabolic flight as a space-flight analogon impacts angiogenesis and lipid metabolism.
Life Sci Space Res (Amst)
August 2025
Paracelsus Medical University, Salzburg, Austria; Rehabilitation Center Moorheilbad Harbach, Moorbad Harbach, Austria; Rehabilitation Center Lebens.Resort Ottenschlag, Ottenschlag, Austria.
This study aimed to examine the effects of weightlessness and microgravity, induced by parabolic flight, on specific biomarkers associated with angiogenesis, lipid homeostasis, and cardiovascular diseases, including angiogenin (ANG), angiopoietin-1 (ANGPT-1), angiopoietin-like protein 4 (ANGPTL4), heat shock protein 70 (HSP70), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and platelet-derived growth factor subunit AA (PDGF-AA). 14 healthy volunteers (mean age: 28.9 years; 6 females) participated in short-term sessions of weightlessness and microgravity using parabolic flights.
View Article and Find Full Text PDFParabolic flight as a research platform to investigate ophthalmic changes in microgravity.
Life Sci Space Res (Amst)
August 2025
Center for Space Medicine, Baylor College of Medicine, Houston, Texas, United States; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas, United States; The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, United States; De
Parabolic flight serves as an important terrestrial analog to study acute physiological changes in microgravity without the need for space travel. During a parabolic flight, alternating hypergravity and microgravity phases, lasting up to 40 seconds, enable research into ophthalmic changes. In this review, we discuss the application of parabolic flight as a platform to study microgravity-related changes that might impact ophthalmology including intraocular pressure, intracranial pressure, choroidal blood flow, and modified eye movement patterns.
View Article and Find Full Text PDFBlood flow restriction exercise during microgravity exposure in parabolic flight.
Exp Physiol
August 2025
Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle Upon-Tyne, UK.
This case report evaluates whether it is possible to perform blood flow restriction (BFR) exercise during exposure to microgravity. The objectives were three-fold: (1) to determine if a personalised tourniquet system (PTS) hardware technology performs nominally and enables BFR exercise in microgravity; (2) to determine if BFR augments the exercise stimulus in microgravity in a similar manner to its application on Earth; and (3) to evaluate tolerance and acceptability of performing BFR exercise and operating the PTS hardware in microgravity. Two participants performed resistance squat and deadlift exercises on a flywheel device (inertia of 0.
View Article and Find Full Text PDF