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Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by the SFTS virus (SFTSV). Since the first reported case, SFTSV has spread globally, particularly in Asian regions such as China, South Korea, and Japan, with an increasing number of cases and a high mortality rate among severe patients. SFTSV is an RNA virus capable of rapid biological evolution through genetic mutations, reassortment, and homologous recombination. The disease primarily occurs in mountainous, forested, and hilly areas. Due to limited clinical research, the clinical characteristics and pathogenesis of SFTS remain incompletely understood. This review summarizes recent advances in the regional epidemiological characteristics, clinical features, genotyping, pathogenesis, and rapid detection methods of SFTSV.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325320 | PMC |
http://dx.doi.org/10.3389/fmicb.2025.1622394 | DOI Listing |
JACC Case Rep
September 2025
Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.
Background: Surgical treatment for infective endocarditis (IE) with severe thrombocytopenia is considered high risk and is often avoided.
Case Summary: A 67-year-old man with a history of 3 open-heart surgeries presented with fever and severe thrombocytopenia accompanied by a bleeding tendency. Blood cultures and transthoracic echocardiography confirmed IE of the aortic bioprosthetic valve caused by Candida parapsilosis.
Int J Infect Dis
September 2025
Service de Médicine et Chirurgie Pédiatrique, Centre Hospitalier de Cayenne, 3 Avenue Alexis Blaise, 97300 Cayenne, Guyane Française; Centre de référence de la drépanocytose, Centre Hospitalier de Cayenne, 3 Avenue Alexis Blaise, 97300 Cayenne, Guyane Française; UFR Santé Hyacinthe BASTARAUD
Patients with sickle cell disease (SCD) infected with dengue virus are at high risk of developing severe complications. However, the optimal management approach for this patient population remains unclear. We report two cases of dengue-associated multiorgan failure in adolescents with hemoglobin SC (HbSC) disease, both of whom recovered following structured symptomatic management.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Department of Urology, Shandong Provincial Third Hospital, Shandong University, Jinan, 250012, China; Shandong Stone Disease Prevention and Treatment Center, Jinan, 250012, China. Electronic address:
Introduction: The Multiple primary malignant tumors (MPMT) refers to the occurrence of two primary malignant tumors in the same organ or organs in the same patient at the same time. However, MPMT is rare in the urinary system. Congenital urinary tract anomalies (e.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Department of General Surgery A21, Charles Nicolle University Hospital, Faculty of Medicine of Tunis, Tunisia.
Introduction And Importance: Foreign body ingestion is a significant clinical concern, particularly among elderly and psychiatric patients, often leading to complications such as intestinal obstruction. In this article, we present an intriguing case of dual intestinal and urinary obstruction caused by the ingestion of a dental bridge in a patient with Bricker urinary diversion. Through this rare case, we aim to explore the diagnostic and therapeutic challenges associated with such incidents, supported by a comprehensive review of the literature.
View Article and Find Full Text PDFJ Med Virol
September 2025
Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
The pathogenesis of dengue remains complex and incompletely understood. One proposed mechanism involves the virus evading host immune responses through the upregulation and/or secretion of immune-inhibitory molecules. This study investigates the association between plasma levels of soluble human leukocyte antigen G (sHLA-G), a known immunoregulatory molecule, and dengue severity in hospitalized patients.
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