Adolescent pregnancy in French Guiana: double trouble for young mothers and small vulnerable newborns.

Objectives: Adolescent pregnancies (AP), defined as pregnancies in girls aged 10-19 years, are associated with adverse maternal and neonatal outcomes. They are frequently reported among those with low economic status. French Guiana (FG) is a French overseas territory with important social inequalities in South America, marked by inequalities.

Managing Life-Threatening Complications of Dengue Fever in Two Sickle Cell Disease Patients: A Case Series.

Patients with sickle cell disease (SCD) infected with dengue virus are at high risk of developing severe complications. However, the optimal management approach for this patient population remains unclear. We report two cases of dengue-associated multiorgan failure in adolescents with hemoglobin SC (HbSC) disease, both of whom recovered following structured symptomatic management.

Association of Asthma with Acute Vaso-Occlusive Crisis Among French Guianese Children with Sickle Cell Disease.

Objectives: To evaluate the impact of asthma on hospitalizations for acute vaso-occlusive pain episodes in children with sickle cell disease (SCD).

Methods: A multicenter nested case-control study was conducted over a period from January 1, 2012, to December 31, 2022.

Results: The mean age of the study population was 8.

Study of Uprooting in Pediatric Cancer Care for Children From the French West Indies and Guiana Treated in Mainland France: A Qualitative Study.

Background: A diagnosis of childhood cancer has a profound impact on families, especially when treatment requires relocation. Children from the French West Indies (FWI) and French Guiana (FG) are often treated in specialized centers in mainland France, resulting in physical and cultural uprooting that poses unique psychosocial challenges.

Aims: This study explores the impact of uprooting on the dynamics and well-being of these families.

Parental Low Level of Education and Single-Parent Families as Predictors of Poor Control of Type 1 Diabetes in Children Followed in French Guiana.

This study aimed to determine the prevalence of type 1 diabetes mellitus (T1DM) in French Guiana and describe the social profiles of the patients. We conducted a multicenter cross-sectional study of children under 18 years who were diagnosed with type 1 diabetes and followed up from 2002 to 2021. Over a 20-year period, 48 children under 18 years with type 1 diabetes living in French Guiana were included in the study, out of a total of 59 cases.

Breaking barriers: Enhancing hospital support for sickle cell disease management.

Background: Sickle cell disease (SCD) management requires comprehensive care coordination and specialised resources, particularly in endemic regions. We describe the implementation and outcomes of a unique model, the Integrated Centre for Sickle Cell Disease (CID), in French Guiana, a region with high SCD prevalence.

Design And Methods: We established a comprehensive SCD care centre incorporating dedicated clinical space, specialised staff, and integrated emergency services.

A comprehensive evaluation of cardiac amyloidosis epidemiology and diagnostics in French Guiana.

Background: Cardiac amyloidosis (CA) is a potentially fatal systemic disease that has received increasing attention in recent years. However, there is no data on its epidemiology in French Guiana. This study aimed to evaluate the epidemiological characteristics of cardiac amyloidosis and describe the regional diagnostic pathways in French Guiana.

Guidelines for the management of emergencies and critical illness in pediatric and adult patients with sickle cell disease.

Forty-two questions were evaluated concerning management of emergencies and critical illnesses in paediatric and adult patients with sickle cell disease. The assessment covered the following areas: patient referral, vaso-occlusive crisis, acute chest syndrome, transfusion therapy, and priapism. The patient referral category included guidelines for admission to intensive care unit and management at specialized reference centers.

Emergency Presentations of Pediatric Sickle Cell Disease in French Guiana.

Background/objectives: This study aimed to estimate the proportion of pediatric emergency admissions related to sickle cell disease.

Methods: This is a cross-sectional study. The data were collected over a period of 9 years, from 1 January 2014 to 31 December 2022.

Precariousness Represents an Independent Risk Factor for Depression in Children With Sickle Cell Disease.

While the prevalence and impact of depression have been widely described in sickle cell disease, its relationship with precariousness has never been studied. This study aimed to describe the prevalence of depression and its relationship with clinical and demographic factors including social precariousness in children with sickle cell disease in French Guiana. We included children aged 12-18 years with sickle cell disease from the Sickle Cell Reference Center in French Guiana.

Preeclampsia risk factors in French Guiana: a great heterogeneity among populations and geographic areas.

Background: French Guiana is France's largest overseas territory, accounting for 1/6th of mainland France. French Guiana has the highest fertility rate in France and Latin America. However, infant mortality, especially neonatal mortality, remains 2.

Asthma Is an Independent Risk Factor for Acute Chest Syndrome in Children with Sickle Cell Disease in French Guiana.

The overall incidence of asthma in children with sickle cell disease in French Guiana is unknown. Asthma is common in children with sickle cell disease and is associated with increased morbidity and mortality. This study aimed to describe the impact of asthma on the occurrence of acute chest syndrome in children with sickle cell disease who were followed up in French Guiana.

Bone and Joint Infections in Children With Sickle Cell Disease in French Guiana: A 13-Year Retrospective Multicenter Review.

Introduction: Sickle cell disease (SCD) is a genetic disorder with a high infectious morbidity and mortality and a heterogeneous distribution in France. One of the challenges is to differentiate a bone and joint infection (BJI) from a vaso-occlusive crisis. This challenge is particularly prevalent in French Guiana, an overseas territory with the highest incidence of SCD in France.

Clinical outcomes of COVID-19 in patients with sickle cell disease in French Guiana.

Objectives: French Guiana also suffered concrete epidemiological consequences of the SARS-CoV2 epidemic. These regions are home to a large number of sickle cell patients who are at risk of developing severe forms of COVID-19. This study aimed to describe the characteristics and prognosis of patients with sickle disease infected with SARS-CoV2 during the first and second epidemic waves of 2020 in French Guiana.

Timing of infant mortality in French Guiana: The persistence of high post neonatal mortality.

Background: Infant mortality in French Guiana, a French overseas territory, is 2.7 times greater than in mainland France. Given the importance of better understanding infant mortality we aimed to describe the early & late neonatal, and postneonatal mortality in French Guiana between 2007 and 2022.

[Sickle cell disease in French Guiana: assessing 30 years of neonatal screening (1992-2021)].

Background: Sickle cell disease is one of the most common genetic diseases in France. In French Guiana, neonatal screening was introduced in 1992, at the same time as other screening programs for childhood diseases. The aim of this study is to describe the organization of newborn screening for sickle cell disease in French Guiana.

Incidence of Pediatric Cancers in French Guiana: How Does It Compare to Global Estimates?

French Guiana is a French territory in South America. The exposome of persons living there is quite different from that in mainland France and the ethnic make-up of the population is also quite different. Poverty is also widespread with difficulties in accessing care magnified by the low medical-professional density.

Small for Gestational Age Newborns in French Guiana: The Importance of Health Insurance for Prevention.

Small for gestational age (SGA) newborns have a higher risk of poor outcomes. French Guiana (FG) is a territory in South America with poor living conditions. The objectives of this study were to describe risk factors associated with SGA newborns in FG.

Genetic Information to Share with Parents when Newborn Screening Reveals the Presence of Sickle Cell Trait.

The primary purpose of newborn screening for sickle cell disease is to diagnose the disease before the appearance of symptoms and to initiate early treatment. To answer the question "What genetic information needs to be communicated to parents when newborn screening reveals the presence of a sickle cell trait," we conducted a survey using a self-administered online questionnaire. We received responses from 122 healthcare workers and members of sickle cell disease associations, in France and French overseas departments.

Hydroxyurea is associated with later onset of acute splenic sequestration crisis in sickle cell disease: Lessons from the European Sickle Cell Disease Cohort-Hydroxyurea (ESCORT-HU) study.

Acute splenic sequestration crisis (ASSC) is a potentially life-threatening complication of sickle cell disease (SCD), typically occurring in young patients under 5 years of age, with a median age at first episode of less than 2 years. Because a beneficial effect of hydroxyurea (HU) on spleen perfusion and splenic function has been suspected, we hypothesized that HU treatment might be associated with later onset of ASSC in patients with SCD. To investigate this hypothesis, we analyzed data from the ESCORT-HU study on a large cohort of patients with SCD receiving HU, enrolled between January 2009 and June 2017 with a follow-up of 7309 patient-years of observation.

Real-world observational study on the long-term effect of L-glutamine treatment on renal parameters of adult and pediatric patients with sickle cell disease.

Background: Sickle cell disease (SCD) is a rare genetic blood condition affecting millions worldwide. Oxidative stress is a key player in the pathogenesis of SCD and its comorbid consequences. Renal function impairment is a common complication of SCD in both pediatric and adult patients with serious consequences leading to increased risk of mortality.