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Health policies must be continually updated as new evidence is generated to ensure the optimal delivery of health interventions and prevention measures. Models are often used to study health problems, but their complexity limits their use by policy-makers. One way to facilitate their use among non-modellers is to develop user-friendly interfaces and make them available online. We conducted a scoping review of journal articles to identify and describe the currently available, interactive, freely available web-based health models that aim to inform health policy relevant to any disease or health issue affecting human populations. This scoping review included 16 web-based models covering 13 diseases or health issues, of which the most common were coronavirus disease 2019 (COVID-19) and malaria. The most common model outputs were epidemiological indicators (14/16), such as case numbers, incidences, or results from diagnostic screening, followed by the cost of implementing the intervention or health measure of interest (10/16). Model validation was performed in 6 of the 16 studies by comparing the model results with the previously published evidence or comparing simulated outcomes with observed data. Sensitivity and scenario analyses were conducted for 62.5% of models (10/16); however, in most cases, the user can perform these analyses by changing the model parameters in the user interface. This review explores the potential of web-based models to support health policy decisions and resource allocation. Despite their limited number, the 16 interactive web-based health models provide valuable insights into various health issues, primarily infectious diseases. The usability of the currently available web-based health models is impacted by the accuracy of the model description, the ability of the user to alter parameter values and the model assumptions that limit their generalizability. Such models must be validated and incorporate appropriate sensitivity analyses to be reliable and helpful to policy-makers.
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http://dx.doi.org/10.1186/s12961-025-01367-z | DOI Listing |
Reprod Biol
September 2025
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 218 Jixi Road, Hefei Anhui230022, China; Key Laboratory of Population Health Across
Current research indicates that polyethylene terephthalate microplastics (PET-MPs) may significantly impair male reproductive function. This study aimed to investigate the potential molecular mechanisms underlying this impairment. Potential gene targets of PET-MPs were predicted via the SwissTargetPrediction database.
View Article and Find Full Text PDFComput Biol Med
September 2025
INSIGNEO Institute for in silico medicine, University of Sheffield, UK; School of Mechanical, Aerospace and Civil Engineering, University of Sheffield, UK. Electronic address:
Modelling cardiovascular disease is at the forefront of efforts to use computational tools to assist in the analysis and forecasting of an individual's state of health. To build trust in such tools, it is crucial to understand how different approaches perform when applied to a nominally identical scenario, both singularly and across a population. To examine such differences, we have studied the flow in aneurysms located on the internal carotid artery and middle cerebral artery using the commercial solver Ansys CFX and the open-source code HemeLB.
View Article and Find Full Text PDFMutat Res Rev Mutat Res
September 2025
Institute of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address:
To maintain genomic stability, cells have evolved complex mechanisms collectively known as the DNA damage response (DDR), which includes DNA repair, cell cycle checkpoints, apoptosis, and gene expression regulation. Recent studies have revealed that long non-coding RNAs (lncRNAs) are pivotal regulators of the DDR. Beyond their established roles in recruiting repair proteins and modulating gene expression, emerging evidence highlights two particularly intriguing functions.
View Article and Find Full Text PDFJ Trace Elem Med Biol
September 2025
Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. Electronic address:
Objective: We previously documented that exposure to a spectrum of elements is associated with autism spectrum disorder (ASD). However, there is a lack of mechanistic understanding as to how elemental mixtures contribute to the ASD development.
Materials And Methods: Serum and urinary concentrations of 26 elements and six biomarkers of ASD-relevant pathophysiologic pathways including serum HIPK 2, serum p53 protein, urine malondialdehyde (MDA), urine 8-OHdG, serum melatonin, and urine carnitine, were measured in 21 ASD cases and 21 age-matched healthy controls of children aged 6-12 years.