Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Sepsis is a life-threatening organ dysfunction. To explore the predictive value of platelet parameters and hemorheological indicators for mortality risk in elderly sepsis patients. The clinical data of 86 elderly patients with sepsis admitted to the intensive care unit of our hospital from June 2020 to June 2023 were retrospectively analyzed. According to the survival outcome, the patients were divided into the death group (28 cases) and the survival group (58 cases). The platelet parameters and hemorheological indicators of the two groups were compared. Pearson correlation analysis was used to analyze platelet parameters, hemorheology and Sequential Organ Failure Assessment (SOFA). Patients in the death group had higher APACHE II score, SOFA score, MPV, plasma viscosity, Equation K Value of ESR, and RDW than those in the survival group (P < 0.05). SOFA score was positively correlated with MPV, plasma viscosity, Equation K Value of ESR and RDW (P < 0.05), but not correlated with PLT and PDW (P < 0.05). APACHE II score, SOFA score, MPV, plasma viscosity, Equation K Value of ESR, and RDW were risk factors for mortality in elderly sepsis patients (P < 0.05). The joint prediction had higher performance than individual indicator (all P < 0.05). MPV, plasma viscosity, equation K value of ESR, and RDW were related to multiple organ failure in elderly sepsis patients, and could be used to predict the risk of death in patients, with good predictive performance.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318417 | PMC |
| http://dx.doi.org/10.1186/s12871-025-03222-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The inhibitory effect of antiplatelet drugs on spontaneous platelet aggregation on glass surfaces: an analysis based on microscopic three-dimensional topography.
J Thromb Thrombolysis
September 2025
Central Laboratory of Yongchuan Hospital, Chongqing Medical University, No. 439, Xuanhua Road, Yongchuan District, Chongqing, 402160, China.
In vitro assessment of the inhibitory effect of antiplatelet drugs on platelet aggregation is frequently employed to guide personalized antiplatelet therapy in clinical practice. However, existing methods for detecting platelet aggregation rely heavily on high concentrations of exogenous agonists, which may obscure part of the inhibitory effect of antiplatelet drugs and lead to an underestimation of their effects. This study validates a novel analytical strategy for evaluating the effects of antiplatelet drugs by quantifying the microscopic three-dimensional morphological parameters of platelet aggregates formed through spontaneous aggregation on a glass surface.
View Article and Find Full Text PDFBackground: Nucleophosmin 1 (NPM1) mutations represent one of the most frequent genetic alterations in acute myeloid leukemia (AML). However, the prognostic significance of concurrent molecular abnormalities and clinical features in NPM1-mutated AML remains to be fully elucidated.
Methods: We retrospectively analyzed 73 adult AML patients with NPM1 mutations.
Background: Based on the widespread use of the systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), markers, we aimed to calculate and compare the reference intervals (RIs) of these indices in adults, using both nonparametric method according to the Clinical and Laboratory Standards Institute's (CLSI) EP28-A3C:2010 guideline and refineR algorithm using a large dataset.
Methods: We analyzed data from 293,585 adults (18 - 65 years) retrospectively obtained from complete blood count results (using laboratory information system). The study involved a two-stage outlier exclusion process.
Antiepileptic Drugs and Influenza A Infection Complicated with Severe Thrombocytopenia.
Clin Lab
September 2025
Background: Patients with epilepsy often require long-term antiepileptic medications, which can affect hematological parameters. Influenza (H1N1) infection is known to potentially cause thrombocytopenia. This case examines the clinical implications of a 29-year-old female patient with epilepsy who developed influenza and significant platelet reduction.
View Article and Find Full Text PDFA Web-Based Dynamic Nomogram for Early Diagnosis in Sepsis: Development and Validation with Real-World Clinical Utility.
Infect Drug Resist
September 2025
Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People's Republic of China.
Purpose: Sepsis has high mortality and progresses rapidly, requiring early diagnosis; traditional scoring and lab parameters are limited in non-ICU settings, highlighting the need for biomarker integration and continuous monitoring to enhance diagnostic accuracy.
Patients And Methods: A retrospective analysis of 1,098 patients at Taizhou Hospital of Zhejiang Province identified sepsis and non-sepsis groups per Sepsis 3.0 criteria, Logistic regression analyses were used to identify the risk factors.