Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Plasmalogens are natural glycerophospholipids that account for approximately 15%-20% (mol%) of human tissues' cellular membrane phospholipid composition. They play an important role in lipid membrane organization and function, including acting as endogenous antioxidants. Plasmalogens contain a vinyl-ether linked alkyl chain at position sn-1, characteristic of vinyl-ether lipids, and often a polyunsaturated fatty acid (PUFA) acyl chain at position sn-2 of the glycerol backbone. The role of plasmalogens in various patho-physiological processes has been revealed in recent years, including various neurological disorders associated with plasmalogen deficiency. Plasmalogen Replacement Therapy (PRT) is a therapeutic approach that aims to increase plasmalogen levels in the body and address plasmalogen deficiencies in diseases such as age-related neurodegenerative diseases, cardiovascular diseases, certain genetic peroxisomal disorders, and metabolic disorders. We provide a detailed overview of current information on the role of plasmalogens in health and disease. We summarize various strategies for regulating plasmalogen levels and highlight recent advancements in therapeutic applications. We also focus on the potential application of nanomedicine for treating disorders associated with PUFA-lipid and plasmalogen deficiencies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312521 | PMC |
| http://dx.doi.org/10.1096/fba.2025-00010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enzymatic synthesis of inositol plasmalogens from distinct lipid sources using phospholipase D from Streptomyces antibioticus.
Biotechnol Lett
September 2025
The United Graduate School of Agricultural Science, Iwate University, Ueda-3, Morioka, Iwate, 020-8550, Japan.
Plasmalogens are a subclass of glycerophospholipids characterized by a vinyl-ether bond at the sn-1 position; they play several physiological roles including membrane stabilization, antioxidant activity, and signal transduction. While choline, ethanolamine, serine, and glycerol plasmalogens (PlsCho, PlsEtn, PlsSer, and PlsGro) are naturally abundant, inositol plasmalogens (PlsIns) are rare. In contrast to the limited occurrence of PlsIns, phosphatidylinositol is a biologically crucial lipid, and its enzymatic biosynthesis from phosphatidylcholine has been extensively studied.
View Article and Find Full Text PDFBis(l-leucinium) hexa-chlorido-stannate(IV) dihydrate.
IUCrdata
August 2025
Univ Rennes CNRS ISCR (Institut des Sciences Chimiques de Rennes), 35042 Rennes France.
The title compound, (CHNO)[SnCl]·2HO, features l-leucinium cations adopting extended conformations, which maximizes the separation between the methyl groups [-CH(CH)] and the polar NH and COOH moieties. Additionally, an intra-molecular hydrogen bond between the ammonium (NH ) group and the carboxyl group induces a slight reduction in the C-C-N bond angles, with an average value of 106.5°, compared to the ideal tetra-hedral angle of 109.
View Article and Find Full Text PDFMacrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine that acts as a central regulator of inflammation and immune responses across diverse organ systems. Functioning upstream in immune activation cascades, MIF influences macrophage polarization, T and B cell differentiation, and cytokine expression through CD74, CXCR2/4/7, and downstream signaling via NF-κB, ERK1/2, and PI3K/AKT pathways. This review provides a comprehensive analysis of MIF's mechanistic functions under both physiological and pathological conditions, highlighting its dual role as a protective mediator during acute stress and as a pro-inflammatory amplifier in chronic disease.
View Article and Find Full Text PDFStructure-Tunable Fluorinated Polyester Electrolytes with Enhanced Interfacial Stability for Recyclable Solid-State Lithium Metal Batteries.
Adv Mater
September 2025
Department of Mechanical Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.
Polyesters, with their tunable chemical structures and environmental sustainability, have drawn growing attention as solid polymer electrolytes for next-generation solid-state lithium metal batteries (SSLMBs). Through a comprehensive experimental and theoretical study involving the systematic variation of carbon chain lengths in the flexible (diol) and coordinating (diacid) segments, along with selective fluorination at distinct positions along the polymer backbone, 18 types of polyester are fabricated and demonstrate that fluorination at the coordinating segment significantly enhances ionic conductivity by suppressing crystallinity. In contrast, fluorination at the flexible segment reduces ionic migration barriers by providing more homogeneous coordinating sites, thereby improving the lithium-ion transference number, despite increasing chain rigidity and a reduction in overall ionic conductivity.
View Article and Find Full Text PDFA novel acidic polysaccharide from Isatidis Radix: Structural characterization and immunoregulatory effect in zebrafish.
Int J Biol Macromol
September 2025
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Provincial Key Laboratory of Functional Substances in Traditional C
The immune system is the ultimate defense against diseases and its dysregulated homeostasis greatly threatens human health. Natural polysaccharides have a variety of biological activities and show promising applications in immunomodulation. In this study, we characterized the structure of the polysaccharide IRPS-TE-3 from Isatidis Radix using morphological analysis, molecular weight analysis, monosaccharide composition analysis, methylation analysis and nuclear magnetic resonance spectroscopy.
View Article and Find Full Text PDF