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Aim: The objective of this study is to investigate interoceptive awareness-defined as the ability to perceive and interpret bodily signals-in individuals diagnosed with chronic heart failure, along with the factors that may influence this awareness. This research aims to establish a theoretical foundation for the development of psychoeducational programs focused on interoception, such as mindfulness-based symptom awareness training, and digital health interventions specifically designed for patients with chronic heart failure (CHF).
Methods: A total of 406 patients diagnosed with congestive heart failure were selected as research subjects through convenience sampling from the cardiology departments of six county hospitals in Nantong City, during the period from January 2025 to March 2025. Cross-sectional surveys were conducted using various instruments, including general information questionnaires, the Multidimensional Internal Perception Assessment Questionnaire, the Social Support Scale, the Self-Rating Depression Scale, and the Memorial Heart Failure Symptom Assessment. To identify the factors influencing internal perception among CHF patients, both univariate and multivariate linear regression analyses were employed.
Results: The overall score of the Multidimensional Assessment of Interoceptive Awareness 2C (MAIA-2C) for individuals diagnosed with congestive heart failure was recorded at 108.44 ± 15.93, within a scale range of 31-155, indicating a moderate-to-high degree of internal perception. A multivariate linear regression analysis identified several independent factors that significantly influence internal perception among CHF patients. These factors include place of residence, the frequency of hospitalizations due to heart failure in the past year, body mass index, levels of depression, availability of social support, and symptom burden.
Conclusion: The internal perception ability of patients with congestive heart failure is influenced by various factors, including their residential environment, the number of hospitalizations related to heart failure in the past year, body mass index, levels of depression, the availability of social support, and symptom burden. In clinical settings, it is essential to consider the level of internal perception among patients. Furthermore, tailored intervention strategies should be developed, taking into account these influencing factors, in order to improve patients' self-management skills and overall quality of life.
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http://dx.doi.org/10.3389/fpsyg.2025.1618068 | DOI Listing |
J Palliat Care
September 2025
Department of Healthcare Administration and Policy, School of Public Health, University of Nevada, Las Vegas, NV, USA.
ObjectivesRecently, atrial fibrillation (AF) has contributed to an increase in cardiovascular deaths in the U.S. Palliative care (PC) and atrial ablation (AA) procedure can elevate quality of life of high-risk AF patients, who are associated with multiple comorbidities.
View Article and Find Full Text PDFPLoS One
September 2025
Biobank of Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China.
Heart failure (HF) and lung cancer (LC) often coexist, yet their shared molecular mechanisms are unclear. We analyzed transcriptome data from the NCBI Gene Expression Omnibus (GEO) database (GSE141910, GSE57338) to identify 346 HF‑related differentially expressed genes (DEGs), then combined weighted gene co-expression network analysis (WGCNA) pinpointed 70 hub candidates. Further screening of these 70 hub candidates in TCGA lung cancer cohorts via LASSO, Random Forest, and multivariate Cox regression suggested CYP4B1 as the only independent prognostic marker.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Cardiology, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Introduction: Kidney stone disease is associated with numerous cardiovascular risk factors. However, the findings across studies are non-uniformly consistent, and the control of confounding variables remains suboptimal. This study aimed to investigate the association between kidney stone and cardiovascular disease.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
September 2025
Division of Pediatric Critical Care, Department of Pediatrics, University of California, San Francisco, USA.
Right ventricular (RV) failure is the primary cause of death among patients with pulmonary arterial hypertension (PAH). Patients with congenital heart disease-associated PAH (CHD-PAH) demonstrate improved outcomes compared to patients with other forms of PAH, which is related to the maintenance of an adaptively hypertrophied RV. In an ovine model of CHD-PAH, we aimed to elucidate the cellular, microvascular, and transcriptional adaptations to congenital pressure overload that support RV function.
View Article and Find Full Text PDFJCI Insight
September 2025
Department of Pharmacology, University of Michigan, Ann Arbor, United States of America.
Cardiac hypertrophy is a common adaptation to cardiovascular stress and often a prelude to heart failure. We examined how S-palmitoylation of the small GTPase, Ras-related C3 botulinum toxin substrate 1 (Rac1), impacts cardiomyocyte stress signaling. Mutation of the cysteine-178 palmitoylation site impaired activation of Rac1 when overexpressed in cardiomyocytes.
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