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Creatine is widely regarded as a safe and effective supplement for physical performance but has recently gained attention as a potential cognitive enhancer. Public and commercial enthusiasm for this use has surged, spiking sales, prescriptions and social media engagement despite a body of evidence that, paradoxically, haved remained considerably limited. This article critically examines the growing disconnect between marketing narratives and scientific rigor in the discourse around creatine and brain health. It also explores how biases, both cognitive and structural, shapes how the evidence is interpreted and communicated. Rather than dismissing creatine's potential, the essay argues for greater critical appraisal and transparency in how health claims are evaluated and disseminated, to ensure that conversations remain anchored to what the data can actually support.
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http://dx.doi.org/10.1016/j.tjnut.2025.07.016 | DOI Listing |
Mol Psychiatry
September 2025
Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA.
Background: Anxiety disorders (AnxDs) are highly prevalent and often untreated or unresponsive to treatment. Although proton magnetic resonance spectroscopy (1H-MRS) studies of AnxDs have been conducted for over 25 years, a consensus regarding neurometabolic abnormalities in these conditions is lacking.
Methods: A systematic review and meta-analysis of 1H-MRS studies of AnxDs (social anxiety disorder, generalized anxiety disorder, and panic disorder) identified 25 published datasets meeting inclusion criteria.
Lipids
September 2025
Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, China.
Energy metabolism manipulation strategy, enhancing fat metabolism while reducing the dependence on glucose, is beneficial to improve exercise performance. The multi-ingredient supplements (MIS) mixed with valine, isoleucine, leucine, β-alanine, creatine, L-carnitine, quercetin, and betaine were found to be able to improve the endurance performance of mice, which was associated with a shift of energy substrates from glucose to fatty acids. Thus, we hypothesized that the MIS regulating lipid metabolism contributes to enhancing exercise endurance in mice.
View Article and Find Full Text PDFFront Nutr
August 2025
Badminton Technical and Tactical Analysis and Diagnostic Laboratory, National Academy of Badminton, Guangzhou Sport University, Guangzhou, Guangdong, China.
Objective: A growing body of evidence confirms that nutritional supplementation strategies combined with resistance training can enhance muscle strength and mass in older adults. However, the optimal supplementation approach remains unclear. This study aimed to evaluate the comparative efficacy of different nutritional interventions combined with resistance training on muscle strength and mass in healthy older adults and determine the optimal strategy.
View Article and Find Full Text PDFCell Rep
September 2025
Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuh
Tumor metabolic reprogramming is critical for providing energy to support proliferation and resistance to stress-induced cell death. However, the regulatory mechanisms linking these processes remain incompletely understood. Here, using untargeted metabolomics, we demonstrate that creatine potently induces ferroptosis in colorectal cancer (CRC).
View Article and Find Full Text PDFNutr Metab Cardiovasc Dis
July 2025
Nutrition Innovation Center, Standard Process Inc., Kannapolis, NC, USA. Electronic address:
Background And Aims: Elevated plasma levels of total homocysteine (Hcy) and S-Adenosylhomocysteine (SAH) are associated with increased risks of neurological and cardiovascular diseases (CVD). Whilst elevated plasma levels of Hcy can be managed through supplementation with B-group vitamins, there are no effective therapies for managing SAH in patients with elevated SAH and normal Hcy. SAH, a by-product of cellular methylation reactions, is considered a more sensitive biomarker for CVD than homocysteine (Hcy).
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