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Intramural pregnancy (IMP) is a rare type of ectopic pregnancy where the embryo implants within the uterine myometrium. This condition carries a high risk of massive hemorrhage, uterine rupture, and potentially life-threatening complications. We present a case of a 35-year-old patient who underwent in vitro fertilization (IVF) and was diagnosed with an IMP located in the back-isthmian portion of the uterus by ultrasound scan. We performed a conservative treatment approach based on the gestational sac location and the patient's stable clinical condition and desire for future fertility. We first administered mifepristone 600 mg, followed by intracavitary methotrexate under ultrasound guidance. Although originally planned, a uterine artery embolization was not performed due to the evidence of bilateral anastomoses between the uterine and ovarian arteries. Progressive reabsorption of pregnancy was observed over the course of 8 months. Non-surgical management can be considered for IMP, thus allowing fertility preservation.
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http://dx.doi.org/10.3390/jcm14145146 | DOI Listing |
Nat Commun
August 2025
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
T cell scarcity in tumor tissues poses a critical challenge to cancer immunotherapy. Here we manipulate the tumor vasculature, an essential regulator of immune cell trafficking, to reinvigorate anti-tumor T cell responses in "cold" tumors. We show that ectopic pan-endothelial expression of COUP-TFII, a master transcription factor for venous development, induces molecular programs of post-capillary venules in tumor endothelium.
View Article and Find Full Text PDFJ Clin Med
July 2025
Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy.
Intramural pregnancy (IMP) is a rare type of ectopic pregnancy where the embryo implants within the uterine myometrium. This condition carries a high risk of massive hemorrhage, uterine rupture, and potentially life-threatening complications. We present a case of a 35-year-old patient who underwent in vitro fertilization (IVF) and was diagnosed with an IMP located in the back-isthmian portion of the uterus by ultrasound scan.
View Article and Find Full Text PDFPrz Menopauzalny
March 2025
Department of Obstetrics and Gynaecology, Medical University Pleven, Pleven, Bulgaria.
Interstitial pregnancy (IP) is a rare kind of tubal pregnancy, which occurs in 2-4% of all ectopic pregnancies. It occurs as a result of implantation of the gestational sac in the proximal intramural part of the fallopian tube. Risk factors include the following: pregnancy conceived after assisted reproductive technologies, ipsilateral salpingectomy, previous ectopic pregnancy, congenital tubal and uterine malformations, pelvic inflammatory disease, and the presence of an intrauterine device.
View Article and Find Full Text PDFFront Cell Dev Biol
July 2025
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
There has been renewed interest in neural transplantation of cells and tissues for brain repair. Recent studies have demonstrated the ability of transplanted neural precursor cells and grown organoids to mature and locally integrate into host brain circuitry. Most studies have focused on how the transplant behaves and functions after the procedure, but the extent to which the host brain can properly innervate the transplant, particularly in the context of aging, is largely unexplored.
View Article and Find Full Text PDFFront Med (Lausanne)
June 2025
Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
We present an extremely rare heterotopic pregnancy (HP) in a 33-year-old patient with multiple adenomyosis surgeries and bilateral salpingectomy, who conceived via assisted reproductive technology (ART). According to a review of the literature spanning two decades, concurrent intrauterine and extrauterine pregnancies are uncommon, especially in the case of intramural ectopic gestations. On day 31 post-embryo transfer, only an intrauterine pregnancy (IUP) was observed by ultrasound.
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