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Article Abstract
Objectives: Interventions to prevent dementia among older adults with high-risk conditions such as Mild Cognitive Impairment (MCI) or Major Depressive Disorder (MDD) are highly needed. This study assessed the feasibility, adherence, safety, and clinical effects of home-based Cognitive Remediation (CR) with transcranial Direct Current Stimulation (tDCS) delivered by study partners in these populations.
Design: Open-label study.
Participants: Patients with a diagnosis of MCI, MDD in remission (rMDD), or both, were enrolled as a couple with their study partners.
Intervention: Home-based CR+tDCS, five days/week for eight weeks and then CR online with one week of CR+tDCS boosters every six months for up to two years.
Methods: Nineteen couples were enrolled. Cognitive testing was administered at baseline, after the 8-week phase, and then yearly from baseline for up to two years. Measures of feasibility, adherence and safety and clinical and cognitive outcomes were collected.
Results: Study partners experienced increased perceived competence in delivering the intervention [F (1, 164) = 18.87, p < 0.001]. Eighty percent of the 8-week sessions were completed by 84 % of the patients; 56 % of the patients completed the 2-year intervention. Improvement in global cognition was observed in patients [F (3, 15.1) = 4.04, p = 0.027], and in quality of life in study partners [F (3, 30.6) = 6.18, p = 0.002].
Conclusions: This study demonstrates that home-based CR+tDCS is feasible and safe in patients with MCI or rMDD, and could improve cognition in patients and quality of life in study partners. Randomized controlled trials are needed to confirm these findings.
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| http://dx.doi.org/10.1016/j.inpsyc.2025.100116 | DOI Listing |
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