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ssessing the reliability of two production lines, whether individually or simultaneously, is of significant importance for improving manufacturing processes and guaranteeing superior product quality. This paper examines the reliability assessment of two production lines utilizing joint progressively Type-II censored samples derived from the XLindley distribution. In addition to estimating the unknown parameters, the reliability functions for each production line, as well as for both production lines simultaneously, are analyzed. Both classical likelihood-based and Bayesian methodologies are employed for estimation purposes. The maximum likelihood method is applied to obtain point estimates for the unknown parameters and reliability functions, while Bayesian analysis is performed under the squared error loss function, employing the Markov Chain Monte Carlo technique to generate samples from the posterior distribution. The approximate confidence intervals, percentile bootstrap confidence intervals, and the highest posterior density credible intervals for the unknown parameters and various reliability functions are discussed. The problem of selecting the optimal censoring plan is also considered. A comprehensive simulation study is conducted to assess the performance of the proposed methods, comparing the accuracy and efficiency of the estimates across different censoring schemes. Furthermore, the applicability of the proposed methodology is demonstrated through the analysis of two real-world data sets, underscoring its practical utility within the field of reliability. Finally, three criteria, namely A-optimality, D-optimality, and F-optimality, are considered to determine the optimal censoring plan.
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http://dx.doi.org/10.1038/s41598-025-11493-x | DOI Listing |
Chembiochem
September 2025
School of Biological and Chemical Sciences, Ryan Institute, University of Galway, University Road, Galway, H91 TK33, Ireland.
Activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) is an aggressive cancer with poor response to standard chemotherapy. In search of new therapeutic leads, a library of 435 fractions prepared from the Irish marine biorepository was screened against 2 ABC-DLBCL cell lines (TMD8 and OCI-Ly10) and a non-cancerous control cell line (CB33). Active fractions are prioritized based on potency and selectivity.
View Article and Find Full Text PDFPlant Commun
September 2025
Key Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Ministry of Agriculture, Department of Horticulture, Zhejiang University, Hangzhou 310058, PR China. Electronic address:
With the improvement of living standards, consumers' demands for color diversity and nutritional quality of tomato products have increased. Flavonoid is a considerable index of peel color and nutritional quality in tomato fruit, where flavonoid biosynthesis is controlled by various phytohormones, including brassinosteroids (BRs). However, the underlying mechanism by which BR regulates flavonoid biosynthesis is still unknown.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Department of Chemistry, University of Zurich, CH-8057, Zurich, Switzerland.
Paraptosis is a distinct form of programmed cell death characterized by cytoplasmic vacuolization, mitochondrial swelling, and endoplasmic reticulum (ER) dilation, offering an alternative to apoptosis for therapeutic applications. In this study, we identified a hemicyanine derivative that is a potent paraptosis inducer in two cancer cell lines. This compound triggers hallmark paraptotic features, including ER swelling, mitochondrial morphological changes, increased superoxide production, and caspase-independent cell death.
View Article and Find Full Text PDFGenome Biol
September 2025
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, 430070, China.
Background: Soil salinization represents a critical global challenge to agricultural productivity, profoundly impacting crop yields and threatening food security. Plant salt-responsive is complex and dynamic, making it challenging to fully elucidate salt tolerance mechanism and leading to gaps in our understanding of how plants adapt to and mitigate salt stress.
Results: Here, we conduct high-resolution time-series transcriptomic and metabolomic profiling of the extremely salt-tolerant maize inbred line, HLZY, and the salt-sensitive elite line, JI853.
PLoS One
September 2025
Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria.
Advanced glycation end products (AGEs) and reactive intermediates, such as methylglyoxal, are formed during thermal processing of foods and have been implicated in the pathogenesis of a series of chronic inflammatory diseases. AGEs are thought to directly interact with the intestinal epithelium upon ingestion of thermally processed foods, but their effects on intestinal epithelial cells are poorly understood. This study investigated transcriptomic changes in human intestinal epithelial FHs 74 Int cells after exposure to AGE-modified human serum proteins (AGE-HS), S100A12, a known RAGE ligand, and unmodified human serum proteins (HS).
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