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http://dx.doi.org/10.1038/s41598-025-08992-2 | DOI Listing |
Cornea
September 2025
Department of Ophthalmology, University of California Los Angeles, Los Angeles, CA.
Purpose: To evaluate visual outcomes after bacterial keratitis (BK) and identify predictive factors for poor prognosis at a tertiary referral center in Southern California.
Methods: This is a cross-sectional retrospective review of patients' medical records with culture-positive BK at University of California Los Angeles from January 1, 2014, to December 31, 2019. Main outcome measure was change in best-corrected visual acuity (BCVA) at 12 weeks posttreatment.
PLoS Negl Trop Dis
September 2025
Department of Community and Family Medicine, School of Public Health, University of Zambia, Lusaka, Zambia.
Background: Trachoma is responsible for the blindness or visual impairment of about 1.9 million people and causes about 1.4% of all blindness worldwide.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Mathematical and Statistical Methods (Biometris), Wageningen University, Wageningen, The Netherlands.
Many plant cell functions, including cell morphogenesis and anisotropic growth, rely on the self-organisation of cortical microtubules into aligned arrays with the correct orientation. An important ongoing debate is how cell geometry, wall mechanical stresses, and other internal and external cues are integrated to determine the orientation of the cortical array. Here, we demonstrate that microtubule-based nucleation can markedly shift the balance between these often competing directional cues.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Internal Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
In resource-limited settings in Africa, which harbour the greatest burden of Sickle Cell Disease (SCD) globally, poor care outcomes are driven in part, by a lack of trained healthcare providers (HCP) and an absence of context-specific treatment guidelines appropriate to the level of healthcare facility. The study aimed to evaluate the impact of a structured training program on HCP's knowledge of SCD in Ghana. This was prospective cross-sectional study involving HCPs from 46 health facilities from 4 out of 16 regions in Ghana.
View Article and Find Full Text PDFJ Craniofac Surg
September 2025
University of Miami Miller School of Medicine, Miami, FL.
Outcomes were to compare the accuracy of 2 large-language models-GPT-4o and o3-Mini-against medical-student performance on otolaryngology-focused, USMLE-style multiple-choice questions. With permission from AMBOSS, we extracted 146 Step 2 CK questions tagged "Otolaryngology" and stratified them by AMBOSS difficulty (levels 1-5). Each item was presented verbatim to GPT-4o and o3-Mini through their official APIs; outputs were scored correct/incorrect.
View Article and Find Full Text PDF