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According to the World Health Organization (WHO), 17.9 million people die yearly from cardiovascular Diseases (CVDs), including heart attacks. Cardiovascular diseases, including heart attack, kill 32% of people globally. Current approaches struggle with electrocardiogram (ECG) signal variability, causing diagnosing errors. The adoption of automated and accurate models for heart disease detection is lacking since conventional methods rely on human analysis, which is time-consuming and error-prone. This work covers the crucial topic of heart disease diagnosis, especially ECG data analysis for cardiovascular disease detection. The integration of the Deep-Convolutional Neural Network (Deep-CNN) and Bidirectional Long Short-Term Memory (Bi-LSTM) model with an Attention Mechanism enhances the accuracy and reliability of heart disease categorisation. The Deep-CNN component efficiently extracts features from capture spatial linkages, while the Bi-LSTM layers handle temporal dependencies to identify patient health patterns over time. The model is evaluated on 303 patient records with 14 clinical characteristics from the University of California, Irvine (UCI) Cleveland Heart Disease dataset. The suggested technique has 97.23% accuracy, 97.72% recall, precision, and 96.90% F1 score. These findings show that the proposed architecture improves diagnostic performance more than boosting ensemble approaches and hybrid models.
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http://dx.doi.org/10.1007/s13246-025-01612-3 | DOI Listing |
Infect Dis Ther
September 2025
School of Biomedical Sciences, The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.
Introduction: The high mortality of Coronavirus Disease 2019 (COVID-19) highlights the need for safe and effective antiviral treatment. Small molecular antivirals (remdesivir, molnupiravir, nirmatrelvir/ritonavir) and immunomodulators (baricitinib, tocilizumab) have been developed or repurposed to suppress viral replication and ameliorate cytokine storms, respectively. Despite U.
View Article and Find Full Text PDFStem Cell Rev Rep
September 2025
Department of Medical Genetics and Prenatal Diagnostics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The emergence of organoid models has significantly bridged the gap between traditional cell cultures/animal models and authentic human disease states, particularly for genetic disorders, where their inherent genetic fidelity enables more biologically relevant research directions and enhances translational validity. This review systematically analyzes established organoid models of genetic diseases across organs (e.g.
View Article and Find Full Text PDFClin Rheumatol
September 2025
Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55906, USA.
Objectives: IgG4-related disease (IgG4-RD) can affect multiple organ systems, with coronary artery involvement being rare. Coronary periarteritis may lead to complications such as myocardial infarction and ischemic cardiomyopathy. This case series characterizes the clinical and radiological features, complications, and treatment strategies in patients with IgG4-RD-associated coronary periarteritis.
View Article and Find Full Text PDFPediatr Cardiol
September 2025
Division of Cardiology, Children's National Hospital, 111 Michigan Ave, Washington, DC, 20010, USA.
Patients with acquired and congenital heart disease (CHD) are at higher risk of hospitalization. Despite quality improvement (QI) initiatives, many patients experience readmission soon after discharge. We aimed to identify risk factors for 30-day readmission and hypothesized that direct discharge from the cardiac intensive care unit (CICU) is associated with an increased readmission rate.
View Article and Find Full Text PDFMol Syst Biol
September 2025
Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Vascular sites have distinct susceptibility to atherosclerosis and aneurysm, yet the epigenomic and transcriptomic underpinning of vascular site-specific disease risk is largely unknown. Here, we performed single-cell chromatin accessibility (scATACseq) and gene expression profiling (scRNAseq) of mouse vascular tissue from three vascular sites. Through interrogation of epigenomic enhancers and gene regulatory networks, we discovered key regulatory enhancers to not only be cell type, but vascular site-specific.
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