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Patients with acquired and congenital heart disease (CHD) are at higher risk of hospitalization. Despite quality improvement (QI) initiatives, many patients experience readmission soon after discharge. We aimed to identify risk factors for 30-day readmission and hypothesized that direct discharge from the cardiac intensive care unit (CICU) is associated with an increased readmission rate. A single-center retrospective cohort study was performed of patients discharged from the acute care cardiac unit (ACCU) or CICU from January 1, 2022 to June 30, 2024. Pediatric patients with cardiac disease and adults with CHD were included. Patients with a scheduled readmission were excluded. A total of 1,848 hospitalizations were included, and 223 resulted in readmission within 30 days of discharge. In multivariable analysis, no difference was seen in readmission rates between direct CICU discharge or ACCU discharge (36 [11%] vs. 187 [12%], p = 0.7, odds ratio [OR] 1.2 [0.8-1.8]). Readmission risk factors included single ventricle anatomy (odds ratio [OR] 1.7, 95% confidence interval [1.1-2.4]), chromosomal anomaly (1.8 [1.3-2.6]), cardiomyopathy (3.3 [2.1-5.2])), tube feeding (1.6 [1.1-2.5]), and increased length of stay (1.5 [1.2-1.7]). Tracheostomy (1.7 [0.8-3.1]), and prematurity (1.3 [0.8-1.9]) were not associated with increased risk. Weekend discharge (0.6 [0.4-0.9]) and surgical hospitalizations (OR 0.6 [0.4-0.8]) were associated with fewer readmissions. Risk factors for 30-day readmission included underlying medical complexity, single ventricle physiology, and increased length of admission. Discharging patients from the CICU was not associated with an increased readmission rate. The risk factors identified were largely non-modifiable, and future QI initiatives should examine the resources allocated to discharge teaching, care coordination, and follow up in these high-risk populations.
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http://dx.doi.org/10.1007/s00246-025-04015-z | DOI Listing |
Stroke
September 2025
Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York. (F.C.P., M.R., M.S., A.K., S.G., S.A., S.P., J.C., D.J.R.).
Background: Major ABO-incompatible platelet transfusions are associated with poor intracerebral hemorrhage (ICH) outcomes, yet drivers for this relationship remain unclear. Brain magnetic resonance imaging (MRI) ischemic lesions after ICH are neuroimaging biomarkers of secondary brain injury and are associated with poor outcomes. Given that ABO-incompatible platelet transfusions can induce immune complex formation, thrombo-inflammation, and endothelial barrier disruption, factors that could exacerbate cerebral ischemia, we explored whether major ABO-incompatible platelet transfusions are risk factors for ischemic lesions on brain MRI after ICH.
View Article and Find Full Text PDFEmerg Med Australas
October 2025
Australian Centre for Health Services Innovation, School of Public Health & Social Work, Queensland University of Technology, Brisbane, Queensland, Australia.
Reliably defining the risk of adverse in-flight events in aeromedical trauma patients could enable more informed pre-departure treatment and guide central asset allocation to achieve better system-level outcomes. Unfortunately, the current literature base specifically examining the in-flight period is sparse. Flight duration is often considered a proxy for the risk of in-flight deterioration; however, there is limited data to support this commonly held assumption.
View Article and Find Full Text PDFCirc Genom Precis Med
September 2025
Division of Cardiology, Emory University School of Medicine, Atlanta, GA. (A.K.Y., A.C.R., L.S.S., A.A.Q., Y.V.S.).
Background: Cardio-kidney-metabolic (CKM) disease represents a significant public health challenge. While proteomics-based risk scores (ProtRS) enhance cardiovascular risk prediction, their utility in improving risk prediction for a composite CKM outcome beyond traditional risk factors remains unknown.
Methods: We analyzed 23 815 UK Biobank participants without baseline CKM disease, defined by -Tenth Revision codes as cardiovascular disease (coronary artery disease, heart failure, stroke, peripheral arterial disease, atrial fibrillation/flutter), kidney disease (chronic kidney disease or end-stage renal disease), or metabolic disease (type 2 diabetes or obesity).
Med J Aust
September 2025
University of New South Wales, Sydney, NSW.
Anxiety disorders are the most prevalent mental illness in Australia and are more common in women relative to men, as well as transgender and gender diverse people relative to cisgender people. Sex and gender differences in anxiety prevalence are likely driven by a combination of factors including differential exposure to different types of stressors and trauma, gendered enculturation of different coping responses and perceived stigma of mental illness, differences in medical comorbidities, and differences in symptom presentations. The established impact of gonadal hormone changes on anxiety risk and symptom presentation across the female lifespan underscore the need for sex- and gender-responsive management of anxiety disorders.
View Article and Find Full Text PDFCirc Genom Precis Med
September 2025
Feinberg School of Medicine, Northwestern University, Chicago, IL (Z.C., P.G., A.G., G.W.).
Background: Genetic variation contributes to atrial fibrillation (AF), but its impact may vary with age. The Research Program contains whole-genome sequencing of data from 100 574 adult participants with linked electronic health records.
Methods: We assessed clinical, monogenic, and polygenic associations with AF in a cross-sectional analysis, stratified by age: <45 years (n=22 290), 45 to 60 years (n=26 805), and >60 years (n=51 659).