A multi-view validation framework for LLM-generated knowledge graphs of chronic kidney disease.

Purpose: The goal of our work is to develop a multi-view validation framework for evaluating LLM-generated knowledge graph (KG) triples. The proposed approach aims to address the lack of established validation procedure in the context of LLM-supported KG construction.

Methods: The proposed framework evaluates the LLM-generated triples across three dimensions: semantic plausibility, ontology-grounded type compatibility, and structural importance.

Comparing laparoscopic transversus abdominis plane block and port-site infiltration in laparoscopic ventral hernia repair: A randomised controlled trial.

Introduction: Adequate analgesia is of utmost importance for apposite in patients undergoing laparoscopic ventral hernia repair (LVHR) for smooth recovery. TAP block and port-site infiltration (PSI) are two most commonly employed methods for pain relief. Therefore, this study was done to compare laparoscopic-guided TAP block versus PSI for post-operative analgesia, hospital stay and rescue dose of analgesic in LVHR.

Silver Molybdate-Decorated Nanocomposites of Tin Diselenide for Improved Tribological Activity.

The tin diselenide (SnSe) nanosheets were prepared using the solvothermal method as an additive to enhance the wear and friction-reducing and load-carrying capacity of paraffin oil (PO). To further enhance the lubrication characteristics of SnSe nanosheets (NSs), AgMoO nanoparticles (NPs) were incorporated through the method. The separately prepared SnSe nanosheets, AgMoO nanoparticles, and their nanocomposites (SnSe/AgMoO) were characterized by p-XRD, FTIR, Raman, HR-SEM, EDX, TEM/HR-TEM, and XPS.

Mid-term outcomes of the patients of achalasia cardia undergoing laparoscopic Heller's myotomy with angle of his accentuation versus laparoscopic Heller's myotomy with Toupet's fundoplication.

Background: The choice of anti-reflux procedure with Laparoscopic Heller's myotomy (LHM) is debatable. LHM with Dor's fundoplication is the most common procedure performed and has shown similar outcomes to LHM with Toupet's fundoplication and LHM with Angle of His accentuation (AOH). The present study describes the mid-term outcomes comparing LHM with AOH and LHM with Toupet's fundoplication.

Sexually Dimorphic Responses Reveal Multifaceted Benefits of Glibenclamide in Traumatic Brain Injury.

Sex disparities in traumatic brain injury (TBI) remain poorly understood. Previous data suggest that males are more susceptible to acute secondary injury processes and cell death, whereas females are more vulnerable chronically. Additional sex-based differences have been reported depending on injury model/severity and post-traumatic neurodegeneration.

Development of superhydrophobic jute for food grain storage applications.

Jute is one of the most abundant, biodegradable, inexpensive, and renewable natural fibers. It is primarily used to store grains. Jute exhibits superior mechanical strength, but its affinity for water remains a significant weakness.

A thin cryobiopsy device compatible with transnasal endoscopy for the gastrointestinal tract.

Luminal organ biopsies are critical for disease diagnosis and are obtained using single-bite forceps inserted through the working channel of large endoscopes. Procedures using these endoscopes frequently require patient sedation or anesthesia and may not be feasible for use in pediatric patients. Additionally, forceps-derived biopsies can suffer from difficulty maintaining tissue orientation, crush artifacts, and lack of precise control of biopsy depth.

Membrane order regulates clathrin-coated pit dynamics but not initiation.

Clathrin-mediated endocytosis involves the remodeling of membranes via the initiation, maturation, and scission of clathrin-coated pits (CCPs). How CCP initiation and dynamics are regulated has been addressed primarily from the perspective of the core proteins that mediate endocytosis. Whether and how the physical properties of the membrane regulate CCP initiation and dynamics are heavily underexplored.

Colorimetric 'Naked-Eye' Chemodosimeter for the Detection of CN Ion: Experimental and Theoretical Studies.

An azo-based chemodosimeter (N'E)-3-hydroxy-N'-(2-hydroxy-5-((4-nitrophenyl)diazenyl) benzylidene)-2-naphthohydrazide () has been synthesized by a two-step method and characterized by FT-IR and H NMR spectroscopies and ESI-MS. Upon addition of CN ion, produces a new absorption band at ∼510 nm and, subsequently, red color in HO/DMSO (7:3 v/v) medium, which is noticeable under naked eye condition selectively. Moreover, Whatman filter paper test strips, previously soaked in solution and dried, are detected to generate red color in the presence of CN ion selectively.

Regioselective oxidative bromination of arenes by a metal-organic framework-confined mono-bipyridyl iron(III) catalyst.

Oxidative bromination of arenes is an effective and environmentally friendly method for synthesizing bromoarenes. We have developed a highly robust zirconium metal-organic framework (MOF)-supported mono-bipyridyl iron(III) chloride catalyst (bpy-UiO-FeCl) for oxidative bromination of arenes using HO as the oxidant and KBr as the bromine source. The bpy-UiO-FeCl catalyst exhibits high conversion rates for various substituted arenes, yielding significant amounts of bromoarenes with excellent regioselectivity and recyclability under mild reaction conditions.

Comparative evaluation of enhanced total extraperitoneal repair and intraperitoneal onlay mesh repair-plus for ventral hernias: A randomised controlled study.

Introduction: Ventral hernia repair techniques have evolved, with enhanced total extraperitoneal repair (eTEP) and intraperitoneal onlay mesh repair-plus (IPOM+) emerging as alternatives. While eTEP avoids complications such as adhesions and infections associated with intraperitoneal mesh placement, its effectiveness compared to IPOM+ remains debated. To compare the outcomes of eTEP and IPOM+ in primary midline ventral hernia repair, focusing on post-operative pain, complications and early recurrence rates.

Low Hemoglobin Causes Hematoma Expansion and Poor Intracerebral Hemorrhage Outcomes.

Background: Although lower hemoglobin levels associate with worse intracerebral hemorrhage (ICH) outcomes, causal drivers for this relationship remain unclear. We investigated the hypothesis that lower hemoglobin relates to increased hematoma expansion risk and poor outcomes using human observational data and assessed causal relationships using a translational murine model of anemia and ICH.

Methods: A multicenter, prospective observational cohort study of 2997 patients with ICH enrolled between 2010 and 2016 was assessed.

Data driven design of ultra high performance concrete prospects and application.

Ultra-high performance concrete (UHPC) is a specialized class of cementitious composites that is increasingly used in various applications, including bridge decks, connections between precast components, piers, columns, overlays, and the repair and strengthening of bridge elements. The mechanical and durability properties of UHPC are significantly influenced by factors such as low water-to-binder ratios, the inclusion of supplementary cementitious materials (SCMs), and fiber reinforcement. Machine learning (ML) has been employed to predict the performance of UHPC and optimize its mixture designs by using various raw materials.

Adhesion strength of tumor cells predicts metastatic disease in vivo.

Although only a fraction of tumor cells contribute to metastatic disease, no prognostic biomarkers currently exist to identify these cells. We show that a physical marker-adhesion strength-predicts metastatic potential in a mouse breast cancer model and that it may stratify human disease. Cells disseminating from murine mammary tumors are weakly adherent, and, when pre-sorted by adhesion, primary tumors created from strongly adherent cells exhibit fewer lung metastases than weakly adherent cells do.

Electrophysiology in disorders of consciousness.

Electroencephalography (EEG) has emerged as a powerful tool in the diagnosis, characterization, and prognostication of patients with disorders of consciousness (DoC). EEG is a well-established monitoring tool for the treatment of specific patient populations with impaired consciousness, such as those with status epilepticus and cardiac arrest. The interrogation of neuronal circuitry using evoked and event-related potentials adds prognostic information in comatose individuals.

Hemoglobin Decrements are Associated with Ischemic Brain Lesions and Poor Outcomes in Patients with Intracerebral Hemorrhage.

Background: Acute ischemic lesions seen on brain magnetic resonance imaging (MRI) are associated with poor intracerebral hemorrhage (ICH) outcomes, but drivers for these lesions are unknown. Rapid hemoglobin decrements occur in the initial days after ICH and may impair brain oxygen delivery. We investigated whether acute hemoglobin decrements after ICH are associated with MRI ischemic lesions and poor long-term ICH outcomes.

Quantification and prediction of human fetal (-)-Δ-tetrahydrocannabinol/(±)-11-OH-Δ-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity.

Prenatal cannabis use is associated with neurodevelopmental deficits, likely due to exposure to the psychoactive cannabinoid, (-)-Δ-tetrahydrocannabinol, and its active metabolite, (±)-11-OH-Δ-tetrahydrocannabinol. To determine causality, preclinical studies mimicking human fetal cannabinoid exposure must be conducted. Here we show cannabinoid concentrations across gestation in maternal plasma and paired fetal tissues in trimester 1 and 2 and maternal plasma and fetal umbilical venous plasma in trimester 3.

A Dual-Color Fluorescence-Based Ratiometric Assay to Measure Endocytic Trafficking of Surface Proteins.

Many membrane proteins on the cell surface are constantly internalized from, and re-delivered to, the plasma membrane. This endocytic cycling, which relies on accurate SNARE-mediated fusion of vesicles containing cargo proteins, is highly important for the function of many proteins such as signaling receptors. While the SNARE proteins that mediate fusion during specific events, such as neurotransmitter and hormone release, in mammalian cells has been heavily studied, the SNARE proteins that mediate surface delivery of specific cargo such as the receptors for these released factors are still not known.

Invasive Aspergillosis With Multiple Locations, Mediastinitis, and Cardiac Invasion.

A 25-year-old man reporting weight loss and constitutional symptoms was empirically treated for tuberculosis. Following acute seizures, the patient underwent cerebral imaging and was diagnosed with multiple nonischemic cerebral lesions. Thoracic imaging revealed fibrosing mediastinitis infiltrating and obscuring the left atrium and left ventricle.

Minimally invasive thymectomy for patients with thymoma: surgical, oncological and neurological outcomes.

Background: Traditionally, sternotomy has been the gold standard approach for the treatment of thymomas. However, interest in minimally invasive techniques such as video-assisted and robot-assisted thymectomy is gaining momentum. Concerns have been raised over the possibility of en-bloc resection using minimal access techniques due to limited working space and increased tumour manipulation leading to tumour breach and recurrence.

Macrophage foam cell-derived mediator promotes spontaneous fat lipolysis in atherosclerosis models.

Ectopic lipid accumulation in macrophages is responsible for the formation of macrophage foam cells (MFCs) which are involved in the crosstalk with the perivascular adipose tissue (PVAT) of the vascular wall that plays a pivotal role in the progression of atherosclerosis. However, the interrelationship between MFCs and PVAT implementing adipocyte dysfunction during atherosclerosis has not yet been established. We hypothesized that MFC-secreted mediator(s) is causally linked with PVAT dysfunction and the succession of atherosclerosis.

Comparative genomic analysis reveals distinct virulence and resistance mechanisms in 21 bacterial fish pathogens.

The rising bacterial infections threaten world aquaculture and wild fish populations, making it imperative to increase the understanding of the mechanisms of pathogenic virulence and resistance. This study applies comparative genomic analysis to 21 bacterial fish pathogens, using whole-genome sequences from public genomic resources and sophisticated bioinformatics tools for screening of virulence factors, mobile genetic elements, antibiotic resistance genes, anti-phage defense mechanisms and secretory systems. We have seen that the different pathogens depict a wide range of variability regarding virulence and resistance potential, which may be attributed to species-specific adaptation.

Anti-tumor potential of high salt in breast Cancer cell lines.

Background: Recent Na-MRI reports show higher salt deposition in malignant breast tissue than in surrounding normal tissue. The effect of high salt on cancer progression remains controversial. Here, we investigated the direct effect of high salt on breast cancer progression in vitro.

Low hemoglobin causes hematoma expansion and poor intracerebral hemorrhage outcomes.

Objectives: Although lower hemoglobin levels associate with worse intracerebral hemorrhage (ICH) outcomes, causal drivers for this relationship remain unclear. We investigated the hypothesis that lower hemoglobin relates to increased hematoma expansion (HE) risk and poor outcomes using human observational data and assessed causal relationships using a translational murine model of anemia and ICH.

Methods: ICH patients with baseline hemoglobin measurements and serial CT neuroimaging enrolled between 2010-2016 to a multicenter, prospective observational cohort study were studied.