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Purpose: Percutaneous nephrolithotomy (PCNL) is an effective treatment for large kidney stones, but wider access paths increase the risk of bleeding. While modern miniaturized PCNL techniques reduce invasiveness, they can compromise stone fragment clearance. This study aims to evaluate the efficacy and safety of a novel PCNL technique utilizing pediatric trocar laparoscopy to enhance visualization and potentially minimize blood loss.
Methods: A single-centered prospective study was conducted at Sultan Agung Islamic Hospital, Semarang, Indonesia, between July and September 2024. Patients with large kidney stones underwent a novel technique replacing PCNL after obtaining informed consent. The primary endpoints measured were stone-free rate and major complications after the procedure.
Results: Forty-four participants were enrolled in this study, with 41 completing it. The 24-hour stone-free rate was 87.8%, improving to 100% at 30 days. The mean operative time was 42 ± 13.6 min, with an average hospital stay of 2.39 ± 0.81 days. No major complications were reported. The mean hemoglobin drop was minimal, and transient postoperative leukocytosis without clinical infection was observed.
Conclusion: This study suggests that a novel technique for treating large kidney stones using a 3.5Â mm laparoscopic trocar in PCNL is considered an effective and safe procedure as an alternative to the standard PCNL procedure.
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http://dx.doi.org/10.1007/s00345-025-05837-5 | DOI Listing |
Circ Genom Precis Med
September 2025
Division of Cardiology, Emory University School of Medicine, Atlanta, GA. (A.K.Y., A.C.R., L.S.S., A.A.Q., Y.V.S.).
Background: Cardio-kidney-metabolic (CKM) disease represents a significant public health challenge. While proteomics-based risk scores (ProtRS) enhance cardiovascular risk prediction, their utility in improving risk prediction for a composite CKM outcome beyond traditional risk factors remains unknown.
Methods: We analyzed 23 815 UK Biobank participants without baseline CKM disease, defined by -Tenth Revision codes as cardiovascular disease (coronary artery disease, heart failure, stroke, peripheral arterial disease, atrial fibrillation/flutter), kidney disease (chronic kidney disease or end-stage renal disease), or metabolic disease (type 2 diabetes or obesity).
Rev Med Liege
September 2025
Service de Chimie clinique, CHU Liège, Belgique.
Chronic kidney disease (CKD), heart failure (HF) and atherosclerotic cardiovascular disease (ASCVD) are pathologies that may remain silent for a long time and thus are largely underdiagnosed in clinical practice. The use of biomarkers may help detect people already suffering from these diseases at an early stage or at increased risk to develop them in a near future. The aim of this article is to discuss the place of the assays of albuminuria, natriuretic peptide (BNP/proBNP) and high-sensitivity troponin as well as lipoprotein(a) to help in the diagnosis and prognosis assessment of individuals at risk of presenting or developing a CKD, HF or ASCVD.
View Article and Find Full Text PDFHGG Adv
September 2025
Department of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany; Medizinische Genetik Mainz, Limbach Genetics, Mainz, Germany. Electronic address:
Cystic kidney disease and related ciliopathies are caused by pathogenic variants in genes that commonly result in ciliary dysfunction. For a substantial number of individuals affected by those cilia-related diseases, the causative gene still remains unknown. Using massively parallel sequencing, we here identified a pathogenic bi-allelic variant in the gene encoding PALS1-Associated Tight Junction Protein (PATJ; also known as Inactivation-No-Afterpotential D-Like, INADL) in an individual with ciliopathy.
View Article and Find Full Text PDFJ Perinatol
September 2025
University of Colorado School of Medicine, Department of Pediatrics, Aurora, CO, USA.
Objective: Determine whether acute kidney injury (AKI) is associated with subsequent late-onset infection (LOI) among extremely low gestational age newborns (ELGAN).
Study Design: Secondary analysis of participants in the Preterm Erythropoietin for Neuroprotection Trial. Infants surviving ≥7 days with sufficient serum creatinine data were included.
Fish Shellfish Immunol
September 2025
College of Marine Sciences, State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and
The closely related cytokines Interleukin-4 (IL-4) and IL-13 regulate the Th2 immune response by interacting with their specific receptor complexes. MicroRNAs (miRNAs) modulate various biological pathways through mechanisms that either repress mRNA translation or promote messenger RNA degradation. The miRNA miR-126b is implicated in fish embryonic development.
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