Recombinant Type III Humanized Collagen Solution for Injection Improves Skin Photoaging in Chinese Population: A Case Series.

Background: Photoaging leads to structural changes in the skin, such as reduced collagen production, contributing to wrinkles, reduced elasticity, and dyspigmentation. Collagen-based treatments have shown promise in skin rejuvenation, but the effectiveness of recombinant type III humanized collagen (RhCol-III) solution for injection in Asian populations has not been widely studied.

Aims: To evaluate the efficacy of RhCol-III solution injections in improving skin quality for rejuvenation among Chinese cases.

Methods: Eight Chinese participants with Fitzpatrick phototype III/IV, presenting with signs of skin photoaging, underwent once a month intradermal injections of 2 mg/mL RhCol-III solution over a 90-day period. Clinical assessments, including VISIA imaging, ultrasound, cutometer, and self-assessed Global Aesthetic Improvement Scale (GAIS) scores, were conducted at baseline, 30, 60, and 90 days postinjection. Key skin parameters such as elasticity, firmness, wrinkle severity, pigmentation, and pore size were evaluated to assess the effectiveness of the RhCol-III solution.

Results: Participants demonstrated significant improvements in skin quality, although variable due to individual response. VISIA imaging indicated enhanced skin tone evenness and radiance. Participants who had visible wrinkle reduction and pore size decrease, on further assessment, were found to have increased dermal thickness and density, along with improved skin elasticity and firmness. Most participants reported high levels of satisfaction with the treatment outcomes, and no significant adverse events were observed.

Conclusions: RhCol-III solution injections appear to be a safe and effective treatment for skin rejuvenation, offering improvements in elasticity, firmness, skin tone, and radiance. This case series brings out the potential of RhCol-III solution in providing substantial anti-photoaging benefits in Chinese facial skin.