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http://dx.doi.org/10.1136/bmj.r1514 | DOI Listing |
J Thorac Oncol
September 2025
Institut du Thorax Curie-Montsouris, Paris, France; Paris-Saclay University, UVSQ-Versailles, France.
Introduction: Amivantamab plus lazertinib significantly improved progression-free and overall survival versus osimertinib in patients with previously untreated, EGFR-mutant advanced NSCLC. EGFR-targeted therapies are associated with dermatologic adverse events (AEs), which can affect quality of life (QoL). COCOON was conducted to assess prophylactic management and improve treatment experience.
View Article and Find Full Text PDFCureus
August 2025
Medical Education and Simulation, It's Your Life Foundation, Corpus Christi, USA.
As more professionals acquire mid-career extra degrees, pursuing a doctorate in the given field is becoming the norm. One of the major challenges of obtaining a mid-career degree is balancing family and professional life, along with the added responsibility of fulfilling curricular educational requirements for a degree. This article aims to highlight and overcome those challenges.
View Article and Find Full Text PDFBMC Psychol
September 2025
Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, ON, M5S 1V4, Canada.
Background: Sexual and gender diverse adolescents and young adults (SGDAYA) experience mental health disparities, yet few empirical investigations into the long-term impact of affirmative treatments on their well-being exist.
Methods: This study explored the longitudinal effects of a brief affirmative cognitive-behavioral therapy (CBT) group intervention (AFFIRM) on the depression and anxiety of SGDAYA (N = 202), as well as how pre-treatment and mid-intervention change mechanisms contributed to their improved mental health. Participants' age ranged from 14 to 29 years old at baseline (M = 22.
Neurology
October 2025
Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, WA.
Background And Objectives: Neuroimaging findings in immune effector cell-associated neurotoxicity syndrome (ICANS) have not been systematically described. We created the chimeric antigen receptor (CAR) T-cell Neurotoxicity Imaging Virtual Archive Library (CARNIVAL), a centralized imaging database for children and young adults receiving CAR T-cell therapy. Objectives of this study were to (1) characterize neuroimaging findings associated with ICANS and (2) determine whether specific ICANS-related neuroimaging findings are associated with individual neurologic symptoms.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Learning when to initiate or withhold actions is essential for survival, requiring the integration of past experiences with new information to adapt to changing environments. The prelimbic cortex (PL) plays a central role in this process, with a stable PL neuronal population (ensemble) recruited during operant reward learning to encode response execution. However, it is unknown how this established reward-learning ensemble adapts to changing reward contingencies, such as reward omission during extinction.
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