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Article Abstract
Objective: The objective of this study was to investigate the relationship of estradiol or body roundness index (BRI), respectively, or the coexistence of their changes with accelerated biological aging in male individuals.
Methods: A cross-sectional study with 1818 male individuals aged 20 to 79 years who participated in the National Health and Nutrition Examination Survey 2015-2016 was conducted, in which positive phenotypic age acceleration value was defined as the occurrence of accelerated biological aging. Weighted multivariate logistic regression models were established to evaluate the independent and joint associations of estradiol and BRI with male accelerated biological aging. Restricted cubic spline models were used to explore whether a nonlinear relationship existed.
Results: An independent association of either serum estradiol or BRI with male accelerated biological aging was significantly shown after adjusting for important covariates. For BRI, such an association was nonlinear, but estradiol did not exhibit a similar nonlinear correlation. Moreover, the coexistence of a high level of serum estradiol and a high level of BRI obviously strengthens such an association in adjusted models, suggesting the cooperative impact of estradiol with BRI.
Conclusions: Both serum estradiol and BRI are significantly associated with accelerated biological aging in male individuals. Integrating high estradiol with high BRI might noticeably reinforce this association.
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