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Objectives: The market for autonomous vehicles (AVs) is developing rapidly, while safety concerns persist as a critical challenge hindering their widespread development and commercialization. Intersections, characterized by highly dynamic and unpredictable traffic conditions, represent particularly high-risk scenarios for AVs. This study systematically investigates the key risk factors influencing collision severity at intersections to enhance AV safety performance.
Methods: This study employs the Autonomous Vehicle Operation Crash Dataset Across The Globe (AVOID) to investigate the key factors influencing the injury severity of AV related collisions. A hybrid analytical framework is proposed, integrating an XGBoost-SHAP model for feature importance analysis and a multinomial logit (MNL) model for statistical inference. Following the factor importance ranking, nine critical determinants were selected to examine their individual effects on injury severity levels. Furthermore, the XGBoost-SHAP approach was utilized to explore interaction effects among significant factors, revealing synergistic relationships between key features.
Results: The results indicate that the majority of crashes at intersections occurred when AVs were stationary or moving at low speeds (17.71% while stopped, 42.76% at speeds below 10 mph). Approximately 58.14% of the crashes involved autonomous driving mode, with an injury rate 14.5% higher compared to manual mode. Factors such as pre-crash movement, crash scene, contact area, pre-crash speed, and autonomous mode significantly influenced injury severity. Crashes occurring during straight-line travel or lane changes in autonomous mode tended to result in more severe injury compared to manual driving. Additionally, crashes in steering direction scenes at speeds between 10 and 20 mph were associated with higher injury severity, and speeds exceeding 20 mph in traffic through scenes led to even more severe injuries.
Conclusions: This study reveals the main factors influencing the severity of collisions in autonomous vehicles and the combination of the following factors that may increase the severity of injuries: autonomous driving mode, lane changing, turning or crossing scenarios, and high-speed driving. The results advance the understanding of autonomous vehicle safety and offer potential implications for enhancing self-driving systems.
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http://dx.doi.org/10.1080/15389588.2025.2520006 | DOI Listing |
BMC Pediatr
September 2025
Department of Neonatology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
Background: Red blood cell (RBC) transfusion is a common intervention for anemia in preterm infants; however, its association with bronchopulmonary dysplasia (BPD) remains debated. While biological mechanisms suggest potential harm, the clinical impact of transfusion frequency on BPD incidence and severity remains unclear.
Objective: To investigate whether RBC transfusion frequency is independently associated with the risk and severity of BPD in preterm infants born before 32 weeks of gestation.
Pediatr Nephrol
September 2025
Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Background: Kidney involvement in pediatric sarcoidosis is rare and often underrecognized, leading to diagnostic delays and treatment challenges. We report six patients with renal sarcoidosis to highlight their diverse presentations and outcomes and challenges in management.
Methods: Medical records of patients diagnosed with renal sarcoidosis during 2020-24 were reviewed.
Nat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFNat Rev Cancer
September 2025
Department of Neurology, Division of Neuro-Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Neurotoxicity is a common and potentially severe adverse effect from conventional and novel cancer therapy. The mechanisms that underlie clinical symptoms of central and peripheral nervous system injury remain incompletely understood. For conventional cytotoxic chemotherapy or radiotherapy, direct toxicities to brain structures and neurovascular damage may result in myelin degradation and impaired neurogenesis, which eventually translates into delayed neurodegeneration accompanied by cognitive symptoms.
View Article and Find Full Text PDFNat Cell Biol
September 2025
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Durotaxis, cell migration along stiffness gradients, is linked to embryonic development, tissue repair and disease. Despite solid in vitro evidence, its role in vivo remains largely speculative. Here we demonstrate that durotaxis actively drives disease progression in vivo in mouse models of lung fibrosis and metastatic pancreatic cancer.
View Article and Find Full Text PDF