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Birth complications, particularly jaundice, are one of the leading causes of adolescent death and disease all over the globe. The main severity of these illnesses may diminish if scholars study more about their sources and progress toward effective treatment. Assured developments were prepared, but they are inadequate. Newborns repeatedly have jaundice as their primary medical concern. A raised level of bilirubin is a symbol of jaundice. Generally, in newborns, hyperbilirubinemia peaks in the initial post-delivery week. The inability to perceive issues early is sufficient for quick treatment, and the resemblance of indications might lead to misdiagnosis. Therefore, appropriate technologies are instantly required. Nowadays, researchers have begun to implement an image-processing model for analyzing jaundice. Paediatricians can detect and classify neonatal jaundice with machine learning (ML) and deep learning (DL) techniques. This study proposes an Early Diagnosis of Neonatal Jaundice Image Classification Using Kernel Extreme Learning Machine (EDNJIC-KELM) approach in the Healthcare Sector. The main intention of the EDNJIC-KELM approach is to build an effective system for diagnosing neonatal jaundice based on advanced methods. Initially, the image pre-processing stage applies the Wiener filtering (WF) method to improve the quality of an image and make it more suitable for analysis by removing the noise. In addition, the vision transformer (ViT) method is employed for the feature extraction process. Furthermore, the EDNJIC-KELM method employs the kernel extreme learning machine (KELM) method for the jaundice image classification. Finally, the enhanced coati optimization algorithm (ECOA) method is implemented for the hyperparameter tuning of the KELM method, which results in a higher classification process. The experimental analysis of the EDNJIC-KELM technique is examined using the Jaundice Image data. The performance validation of the EDNJIC-KELM technique portrayed a superior accuracy value of 96.97% over existing models.
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http://dx.doi.org/10.1038/s41598-025-08342-2 | DOI Listing |
Int J Pediatr Otorhinolaryngol
September 2025
ENT Department, AlShifa Medical Complex, Gaza, Palestine.
Introduction: Congenital hearing loss (CHL) is a significant chronic condition affecting children's development and communication skills. Globally, its incidence is 1.33 per 1000 newborns, but data from Gaza is limited, this study aims to investigate clinical profile, and risk factors associated with congenital hearing loss (CHL) in infants within the Gaza Strip, focusing on the period before the 2023 military escalation.
View Article and Find Full Text PDFJ Perinat Neonatal Nurs
September 2025
Author Affiliations: Department of Radiodiagnosis, Livasa Hospital, Sahibzada Ajit Singh Nagar, India (Dr A. Yadav); Advanced Pediatric Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India (Drs Sivagnanaganesan, J. Yadav, J. Kumar); Department of Pediatrics, All India
Background And Objectives: In vitro studies suggest that oral zinc supplementation reduces enterohepatic circulation of unconjugated bilirubin and serum bilirubin levels. Multiple randomized controlled trials (RCTs) have assessed the efficacy of oral zinc supplementation in reducing bilirubin levels and the need for phototherapy. However, the evidence remains conflicting.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Rationale: Weaver syndrome is a rare congenital overgrowth disorder characterized by a wide spectrum of clinical manifestations that often overlap with other overgrowth syndromes. It is primarily caused by pathogenic variants in the Enhancer of Zeste Homolog 2 (EZH2) gene on chromosome 7q36.1.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Department of Clinical Laboratory Medicine, The Fourth People's Hospital of Nanhai District of Foshan City, 528211 Foshan, Guangdong, China.
Background: Neonatal jaundice affects up to 60% of newborns, with pathological cases frequently associated with impaired bilirubin metabolism and gut microbiota dysbiosis. Although evidence implicates gut microbiota in bilirubin metabolism, the precise mechanisms remain incompletely characterized. This study investigated treatment-associated changes in gut microbiota composition, fecal metabolites, and liver function in neonates with hyperbilirubinemia.
View Article and Find Full Text PDFPediatr Surg Int
September 2025
Department of Pediatric Surgery, Capital Institute of Pediatrics-Peking University Teaching Hospital, Beijing, 100020, China.
Purpose: Biliary atresia (BA) patients presenting after 90 days of age face contentious treatment decisions between Kasai portoenterostomy and direct liver transplantation. This study evaluated outcomes of Kasai portoenterostomy in older BA patients to inform therapeutic decision-making.
Methods: A retrospective multicenter study analyzed 32 BA patients who underwent Kasai portoenterostomy beyond 90 days of age.