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Article Abstract

Sensitivity and selectivity of aromatic oxalates towards HO are proposed as key criteria for selecting substrates for chemiexcited photodynamic therapy (PDT). An increase in the electronegativity of the oxalate reduces both sensitivity and selectivity. The presence of an -substituent increases the efficiency of aromatic oxalate. Oxalate encapsulation in micelles does not change the patterns observed in solution. The biocompatible bis(2-pentyloxycarbonyl-phenyl)oxalate, synthesized for the first time, is a promising oxalate for chemiexcited PDT.

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http://dx.doi.org/10.1039/d5cp01832cDOI Listing

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