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Using culture-based screening of stool specimens, 80.3% of 188 children hospitalized for severe acute malnutrition in Malawi carried extended spectrum cephalosporin resistant Enterobacterales (ESCR-E) at admission. 38.3% of children were colonized with multiple ESCR-E species. Over half of the colonized children did not have recent antibiotic exposure or prior hospitalization.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258776 | PMC |
http://dx.doi.org/10.1101/2025.05.30.25328637 | DOI Listing |
PLoS Pathog
September 2025
State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Coronavirus, a large family of positive-sense RNA viruses, are responsible for both mild and severe respiratory illnesses, ranging from the common cold to life-threatening conditions. Despite significant advances in vaccine and antiviral development, the high mutability of human coronaviruses (HCoVs), such as SARS-CoV-2, presents a major challenge in treating these infections. Effective, broad-spectrum antiviral drugs are urgently needed to address both current and future HCoV outbreaks.
View Article and Find Full Text PDFRadiat Prot Dosimetry
September 2025
Department of Radiation Safety and Security, Paul Scherrer Institute (PSI), Forschungsstrasse 111, 5232 Villigen, Switzerland.
The High-Intensity Proton Accelerator Facility at the Paul Scherrer Institute (PSI) accelerates protons to an energy of 590 MeV with currents up to 2.4 mA, i.e.
View Article and Find Full Text PDFFront Hum Neurosci
August 2025
Signal Processing Laboratory (LTS5), École Polytechnique Féderale de Lausanne (EPFL), Lausanne, Switzerland.
Introduction: Absence of language development is a condition encountered across a large range of neurodevelopmental disorders, including a significant proportion of children with autism spectrum disorder. The neurobiological underpinnings of non-verbal ASD (nvASD) remain poorly understood.
Methods: This study employed multimodal MRI to investigate white matter (WM) microstructural abnormalities in nvASD, focusing on language-related pathways.
Front Pharmacol
August 2025
Department of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, United States.
4-Phenylbutyrate (4-PBA), initially recognized for treating urea cycle disorders, has emerged as a potent therapeutic agent with broad-spectrum potential. As a chemical chaperone, 4-PBA modulates protein folding and reduces endoplasmic reticulum stress. 4-PBA has demonstrated efficacy in treating ocular herpes simplex virus type 1 (HSV-1) infection and HSV-1-induced encephalitis, highlighting its potential as a novel anti-herpetic therapy.
View Article and Find Full Text PDFFront Psychiatry
August 2025
Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Introduction: Autistic adults often face unique challenges in stress management. Conventional tools may not cater to their distinct needs. The Stress Autism Mate (SAM) app was developed to support stress recognition and promote active coping strategies through structured self-monitoring and personalised feedback.
View Article and Find Full Text PDF