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Article Abstract
Herein, we report a facile and versatile copper-catalyzed protocol for the chemo- and regioselective synthesis of highly substituted 2-(trifluoromethyl)pyrroles from readily available starting materials. This one-pot cascade reaction of CFCHN, nitrile, and nitroalkene proceeds efficiently under mild conditions, enabling access to a broad spectrum of 2-(trifluoromethyl)pyrroles. Furthermore, the utility of this method is demonstrated by the synthesis of a series of highly substituted pyrroles bearing both trifluoromethyl and cyano groups.
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