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In the context of global environmental pollution and energy shortages, the use of lightweight designs of railway vehicles has become a key technological approach to improve energy efficiency and reduce carbon emissions. The use of lightweight and high-strength materials such as carbon-fiber-reinforced composites to replace traditional metal vehicle structures holds great application potential. In this study, random track loads and ballast impact loads that may occur during service were considered, and a finite-element model of the electric locomotive coupling protective cover was established. The impact resistance of CFRP, GFRP, and their interlayer hybrid configurations (C/G/C and G/C/G) against structural and ballast impacts were investigated. The calculation results showed that the CFRP protective cover exhibited the best structural impact resistance (with the lowest Tsai-Wu strength failure values), but it also had the largest maximum deformation displacement (2.36 mm) under ballast impact conditions. In contrast, the GFRP protective cover had a higher Tsai-Wu strength failure value, indicating that it had worse structural impact resistance, but it had a lower maximum deformation displacement (2.20 mm) under ballast impact conditions, demonstrating superior ballast impact resistance. The impact resistances of the hybrid-layered protective covers fell between those of the CFRP and GFRP in terms of the structural impact, while their ballast-impact resistance surpassed those of single-fiber configurations.
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http://dx.doi.org/10.3390/ma18133133 | DOI Listing |
JAMA Psychiatry
September 2025
School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.
Importance: Cannabis is the most commonly used illicit drug, with 10% to 30% of regular users developing cannabis use disorder (CUD), a condition linked to altered hippocampal integrity. Evidence suggests high-intensity interval training (HIIT) enhances hippocampal structure and function, with this form of physical exercise potentially mitigating CUD-related cognitive and mental health impairments.
Objective: To determine the impact of a 12-week HIIT intervention on hippocampal integrity (ie, structure, connectivity, biochemistry) compared with 12 weeks of strength and resistance (SR) training in CUD.
Mol Biol Rep
September 2025
School of Arts and Sciences, Department of Natural and Applied Sciences, The American University of Iraq-Baghdad, Baghdad, Iraq.
The COVID-19 pandemic, caused by the continuously evolving SARS-CoV-2 virus, has presented persistent global health challenges. As novel variants emerge, many with enhanced transmissibility and immune evasion capabilities, concerns have intensified regarding the efficacy of existing vaccines and therapeutics. This review provides a comprehensive overview of the current landscape of COVID-19 vaccination, including the development and performance of monovalent and bivalent boosters, and examines their effectiveness against newly emerging variants of interest (VOIs) and variants under monitoring (VUMs), such as JN.
View Article and Find Full Text PDFCurr Atheroscler Rep
September 2025
Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.
Purpose Of Review: Despite major advances in the treatment and prevention of atherosclerotic cardiovascular disease (ASCVD), a substantial burden of residual risk remains Obesity has been redefined as a primary and independent drivers of cardiovascular morbidity and mortality warranting focused attention.
Recent Findings: Obesity is now recognized as a chronic disease and a central contributor to residual cardiovascular risk through mechanisms including systemic inflammation, insulin resistance, dyslipidemia, and endothelial dysfunction. This review addresses the limitations of conventional obesity management and highlights emerging pharmacological therapies targeting the underlying adiposopathy.
Int J Phytoremediation
September 2025
Department of Biotechnology, Jaypee Institute of Information Technology, Noida, India.
The present study aimed to explore the potential of Indian mustard ( L.) for phytoremediation of soil contaminated with ciprofloxacin. The antibiotic ciprofloxacin was selected due to its rapidly increasing presence in soil.
View Article and Find Full Text PDFSmall
September 2025
College of Science, Nanjing Forestry University, Nanjing, 210037, China.
Inspired by the rigid exoskeleton and elastic inner tissues of crustaceans, a bilayer gel integrating high-strength rigidity and soft cushioning with high interfacial adhesion (1060 ± 40 J m ) is developed via a stepwise solid-liquid phase crosslinking strategy. Herein, a prefrozen high-concentration polyvinyl alcohol (PVA) solution forms a solid-state structural framework, while a subsequently cast low-concentration PVA solution generates a flexible layer. Partial thawing of the frozen gel during casting triggers molecular chain interpenetration at the interface, synergistically enhanced by controlled molecular penetration, freeze-thaw cycles, and salt-induced crystallization.
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