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http://dx.doi.org/10.1002/ppul.71058 | DOI Listing |
Int J Gen Med
September 2025
Department of Geriatrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Background: Sepsis is characterized by profound immune and metabolic perturbations, with glycolysis serving as a pivotal modulator of immune responses. However, the molecular mechanisms linking glycolytic reprogramming to immune dysfunction remain poorly defined.
Methods: Transcriptomic profiles of sepsis were obtained from the Gene Expression Omnibus.
Front Immunol
September 2025
Institute of Pulmonary Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Neutrophil extracellular traps (NETs) are DNA-protein structures released during a form of programmed neutrophil death known as NETosis. While NETs have been implicated in both tumor inhibition and promotion, their functional role in cancer remains ambiguous. In this study, we compared the NET-forming capacity and functional effects of NETs derived from lung cancer (LC) patients and healthy donors (H).
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun, China.
Purpose: This research aimed to investigate the association between neutrophil-percentage-to-albumin ratio (NPAR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) with disease severity in patients diagnosed with acute myocarditis.
Methods: A total of 185 patients were diagnosed with acute myocarditis at the First Hospital of Jilin University between 2018 and 2024. The related values of NPAR, SII, SIRI, and AISI were computed based on the pertinent blood indices that were acquired within 12 hours of admission.
Immunooncol Technol
September 2025
Division of Tumor Biology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Background: Breast cancer is a systemic disease, yet the impact of tumor molecular subtype and disease stage on the systemic immune landscape remains poorly understood. In this study, we comprehensively analyzed the systemic immune landscape in a large cohort of breast cancer patients, encompassing all molecular subtypes and disease stages, alongside a control group of healthy donors.
Materials And Methods: Using multi-parameter flow cytometry, we assessed the abundance, phenotype, and activation status of diverse innate and adaptive immune cell populations across peripheral blood samples from 355 breast cancer patients and 65 healthy donors.
Cureus
August 2025
Department of Paediatrics, All India Institute of Medical Sciences, Raebareli, Raebareli, IND.
Introduction: Early recognition of pediatric sepsis is crucial for timely intervention, prevention of mortality, and improving long-term outcomes in children. However, the lack of advanced diagnostics in resource-limited settings poses a significant challenge to early diagnosis and intervention. Complete blood count (CBC) parameters are routinely performed, cost-effective, and readily available, yet their diagnostic utility in pediatric sepsis remains underutilized.
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