Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Cerebral microvascular disease can be triggered in people with diabetes who have chronic hyperglycemia. The aim of our study was to understand what effect diabetes has on the cerebral vasculature. In a rodent model, diabetes caused varying degrees of reduced cerebral vascular density and slowed cerebral blood flow in the brain striatum, basal forebrain, thalamus, hypothalamus, and hippocampus. There is a correlation between vessel density and blood flow velocity and the correlation changes in the diabetic state.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2337/db25-0007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cerebrovascular accidents - Unexpected complication of systemic sclerosis: A scarce case report.
Medicine (Baltimore)
September 2025
Al Mouwasat University Hospital, Damascus University, Damascus, Syria.
Rationale: Systemic sclerosis (SS) is an immune-mediated connective disease characterized by skin fibrosis, microvascular damage, and multisystem manifestations. One of the most important processes in connective tissue disorders is vasculitis. The clinical findings can differ when the disease is presented with an antineutrophil cytoplasmic antibody.
View Article and Find Full Text PDFPre-donationstatintherapytoimprovesolidorgantransplantoutcomes.
Transpl Immunol
September 2025
Intensive Care, Royal Free Hospital, Hampstead, London, United Kingdom.
Background: Inflammatory injury in organ donors, particularly after brain death and during ischemia-reperfusion, contributes to graft dysfunction, rejection, and reduced survival. Statins, beyond their lipid-lowering role, exert pleiotropic anti-inflammatory and immunomodulatory effects, including IL-6 suppression, NF-κB inhibition, immune cell modulation, and potential alteration of exosome secretion.
Methods: Building upon this background, this narrative review synthesises preclinical and clinical evidence on pre-donation statin therapy in solid organ transplantation.
Prenatal Diagnosis of Atretic Cephalocele: Ultrasound Demonstration of Superior Sagittal Sinus Fenestration and Fibrous Stalk, and Potential Role of Brainstem-Tentorium Angle.
J Ultrasound Med
September 2025
Department of Fetal Medicine, Fortis Hospital, Ludhiana, India.
We present two cases highlighting novel prenatal ultrasound findings in atretic cephalocele (AC) using high-resolution ultrasound and microvascular flow imaging. This report includes the first prenatal ultrasound demonstration of key diagnostic AC features: superior sagittal sinus fenestration, observed in the parietal case, and a fibrous dural stalk, identified in both parietal and occipital cases. Both fetuses presented with a small midline scalp lesion, internal echoes, and an underlying bony defect without brain tissue herniation.
View Article and Find Full Text PDFFully Endoscopic Microvascular Decompression for Hemifacial Spasm Using 2-Dimensional/3-Dimensional Endoscopy: Clinical Analysis of 204 Cases.
Oper Neurosurg
September 2025
Department of Neurosurgery and the Training Base of Neuroendoscopic Physicians under the Chinese Medical Doctor Association, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Background And Objectives: Microvascular decompression (MVD) for hemifacial spasm (HFS) is commonly conducted under a microscope. We report a large series of fully endoscopic MVDs for HFS and describe our initial experience with 3-dimensional (3D) endoscopy.
Methods: Clinical data of 204 patients with HFS who underwent fully endoscopic MVD using 2-dimensional (2D) and 3D endoscopy (191 and 13 patients, respectively) from July 2017 to October 2024 were retrospectively analyzed.
CAA-related enlarged perivascular spaces are associated with abnormal angioarchitecture in human brain tissue: A key role for white matter atrophy?
J Cereb Blood Flow Metab
September 2025
iInstitut de Mécanique des Fluides de Toulouse (IMFT), Université de Toulouse, CNRS, INPT, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France.
Cerebral Amyloid Angiopathy, a common age-related small vessel disease leading to hemorrhagic stroke, shares many characteristics with Alzheimer's disease: toxic amyloid deposits, microvascular alterations and enlarged perivascular spaces (EPVS). Together, PVS enlargement, reduced amyloid-β clearance and further accumulation form a vicious cycle underlying disease progression. Yet, the neuropathological correlates of EPVS, including the associated angioarchitecture, are poorly understood.
View Article and Find Full Text PDF