Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: This study explores potential therapeutic strategies by determining the current research status, hotspots, and development trends through bibliometric analysis of the PI3K/Akt in ischemic stroke (IS).
Methods: We searched the Web of Science Core Collection for publications on IS and the PI3K/Akt pathway, covering January 1, 2010, to December 31, 2024. VOSviewer and CiteSpace software were used to analyze research hotspots and cutting-edge topics in the field and generate visual maps of relevant countries, institutions, authors, journals, keywords, and references.
Results: A total of 635 publications were analyzed. The number of publications indicates a steady annual increase in research output. China, Capital Medical University, and Wang Lei were identified as the most prolific country, institution, and author, respectively. The top three contributing journals were , , and . Autophagy, microglia and neuroinflammation, bioinformatics approaches, and traditional Chinese medicine (TCM) are not only current research areas but also important trends for future research. Notably, targeting IS with TCM holds significant potential for translating basic research findings into clinical applications.
Conclusion: This bibliometric analysis provides an in-depth overview of research on the PI3K/Akt pathway in IS, revealing current research status, hotspots, and future research trends. This will provide valuable guidance and direction for developing novel therapeutic strategies targeting this pathway.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230055 | PMC |
| http://dx.doi.org/10.3389/fnmol.2025.1613702 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bibliometric analysis of immune-related acute kidney injury induced by cancer immunotherapy (2000-2025).
Naunyn Schmiedebergs Arch Pharmacol
September 2025
Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, China.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but are increasingly linked to immune-related kidney injury (irKI). This study presents the first bibliometric analysis of irKI research (2000-2025), aiming to identify key trends, mechanistic insights, and pharmacological risk factors. We analyzed 2,179 publications to understand the evolution of irKI research, focusing on areas like T cell-mediated tubular injury, immune system-driven inflammation, and changes in metabolism.
View Article and Find Full Text PDFHispanic Authorship in Orthopaedics: A Bibliometric Analysis of Orthopaedic Literature in the United States.
J Am Acad Orthop Surg Glob Res Rev
September 2025
From the University of California, Riverside, Riverside, CA (Arroyo, Moore); the Birmingham Heersink School of Medicine, University of Alabama, Birmingham, AL (Cruz); the Warren Alpert Medical School, Brown University, Providence, RI (Rodarte); Department of Orthopaedic Surgery, Banner University Sp
Introduction: Orthopaedic surgery has historically been among the least ethnically diverse fields in medicine. The latest American Academy of Orthopaedic Surgeons (AAOS) Census report in 2018 indicates that only 2.2% of all practicing orthopaedic surgeons in the United States identify as Hispanic/Latino.
View Article and Find Full Text PDFExploring research advances and future trends in drug resistance in multiple myeloma: A comprehensive bibliometric analysis.
Medicine (Baltimore)
September 2025
Nanchang Bright Eye Hospital, Nanchang, Jiangxi, China.
Introduction: This bibliometric analysis aims to explore global trends, research hotspots, and future directions in multidrug resistance of multiple myeloma (MM), providing insights for overcoming resistance mechanisms and optimizing therapeutic strategies.
Methods: We analyzed 3300 publications indexed in the Web of Science Core Collection (2015-2024) using CiteSpace and VOSviewer. Multidimensional evaluations of countries/regions, institutions, authors, journals, and keywords were conducted, supplemented by visual network mapping to elucidate research dynamics and collaborative patterns.
Mapping the neuropathic pain biomarker landscape (2004-2024): A bibliometric analysis of thematic evolution, research silos, and the translational gap.
Medicine (Baltimore)
September 2025
Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Background: Despite a surge in neuropathic pain (NP) biomarker research over the past 2 decades, the translation of discoveries into clinical practice remains slow. To understand this translational gap, we conducted a comprehensive bibliometric analysis to map the field's evolution, intellectual structure, and strategic challenges.
Methods: We conducted a bibliometric analysis of NP biomarker-related publications from 2004 to 2024 using the Web of Science Core Collection (WoSCC) database.
Research hotspots and emerging trends of artificial intelligence in the clinical management of mild cognitive impairment: A bibliometric and evidence-based analysis.
Medicine (Baltimore)
September 2025
School of Sports Science and Technology, Guangzhou College of Applied Science and Technology, Guangdong, China.
Objective: This study combines a bibliometric analysis with an umbrella review to delineate the research landscape, hotspots, and emerging trends in the application of artificial intelligence to the clinical diagnosis and treatment of mild cognitive impairment.
Methods: We searched the Web of Science Core Collection for literature published between 2004 and 2024. Bibliometric analysis of the retrieved publications was performed using CiteSpace and VOSviewer to map publication trends, international collaboration networks, key contributors, and keyword co-occurrence.