Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: This cross-sectional survey investigated the incidence of H-type hypertension and associated risk factors in a health checkup population in Urumqi, China. We aimed to identify potential intervention targets by screening patients with H-type hypertension and high-risk populations, filling the gap in the risk assessment of H-type hypertension in high-altitude areas.
Methods: From January 2023 to January 2024, we conducted a cross-sectional study on 1,772 individuals who underwent methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism evaluations. We included a questionnaire survey and collected physical measurements and blood samples. The relative risk factors related to H-type hypertension, as well as their correlation with the MTHFR C677T genotype, were subsequently analyzed.
Results: H-type hypertension was present in 68.96% of hypertension cases and 17.55% of the population in Urumqi who underwent health checkups. The methylenetetrahydrofolate reductase (MTHFR) C677T distributions of the CC, CT, and TT genotypes were 11.90%, 39.87%, and 48.23%, respectively. Moreover, multivariate logistic regression identified the MTHFR C677T TT genotype, age, triglyceride-glucose index (TyG), and carotid plaques as risk factors related to H-type hypertension, with odds ratios (ORs) of 3.044 (p < 0.001), 1.041 (p = 0.001), 1.385 (p = 0.003), and 1.748 (p < 0.001), respectively. In addition, high-density lipoprotein (HDL) cholesterol was identified as a protective factor (OR = 0.447, p = 0.002). Through regression analysis, a nomogram model was constructed to predict the incidence of H-type hypertension. This model showed a good fit, and the area under the receiver operating characteristic (ROC) curve (AUC) was 0.760. Its predicted H-type hypertension incidence was closely related to the actual incidence.
Conclusions: According to our findings, the MTHFR C677T TT genotype in Urumqi, China, serves as a risk locus related to H-type hypertension. Moreover, age, TyG, and carotid plaques are risk factors for H-type hypertension, whereas HDL is a protective factor.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231612 | PMC |
| http://dx.doi.org/10.1186/s12872-025-04926-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Patterns and Correlates of Concurrent Serum Vitamin D, Folate, and Vitamin B Status in a Rural Chinese Population.
J Nutr
August 2025
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:
Background: Vitamin D, folate, and vitamin B are essential micronutrients with widespread insufficiencies globally. Although most previous research examined each of these nutrients individually, few studies have measured biomarkers of these nutrients concurrently in a large population.
Objectives: We aimed to investigate the patterns of concurrent insufficiencies or deficiencies of these nutrients based on serum biomarkers and influencing factors in a rural Chinese population.
Homocysteine, HHcy, H-type hypertension and dizziness: an NHANES analysis.
Front Neurol
July 2025
Department of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Background: Homocysteine (Hcy) is associated with various diseases, but its specific relationship with different types of dizziness remains unclear.
Objectives: This study utilizes NHANES cross-sectional data to investigate the associations between Hcy levels, H-type hypertension, and various symptomatic dizziness, aiming to provide new insights for clinical diagnosis and treatment.
Materials And Methods: This cross-sectional study analyzed 6,970 participants from NHANES (1999-2004) using weighted logistic regression, trend tests, restricted cubic spline analysis, and subgroup analysis.
Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults.
Front Cardiovasc Med
July 2025
Clinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
Backgrounds: The triglyceride-glucose index combined with waist circumference (TyG-WC) has good predictive performance for cardiovascular disease, but the relationship of TyG-WC with H-type hypertension (HTH) is still unclear.
Objects: To explore the association between TyG-WC and HTH, and provide theoretical basis for the prevention and treatment of HTH in the community population.
Methods: The study used multi-stage cluster random sampling to collect representative samples from urban and rural populations in Hunan Province.
CYP1A1/20-HETE/GPR75 Axis-Mediated Arachidonic Acid Metabolism Dysregulation in H-Type Hypertension Pathogenesis.
Int J Mol Sci
June 2025
Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Children's Medical Center, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China.
This study aims to explore the pathogenic mechanism of H-type hypertension. A rat model of H-type hypertension was established through high-methionine dietary intervention, with subsequent folic acid administration. Untargeted serum metabolomic profiling identified a significant reduction in arachidonic acid (AA) levels in the methionine-enriched group, which were effectively normalized following folic acid supplementation.
View Article and Find Full Text PDFCross-sectional study on the association between 24-hour urinary potassium excretion and the risk of H-type hypertension and non-H-type hypertension in Chinese adults.
Front Endocrinol (Lausanne)
July 2025
Department of Chronic Non-Communicable Diseases Control and Prevention, Hangzhou, China.
Objective: Reports on urinary potassium excretion and H-type hypertension remains rare. We aimed to describe the relationship between 24-hour (h) urinary potassium excretion and the risk of H-type hypertension and non-H-type hypertension, thus to guide personal and public health campaigns including dietary recommendations to lower H-type hypertension and non-H-type hypertension in China.
Methods: In 2020 in Zhejiang, China, a cross-sectional survey on Salt Reduction and Prevention of Hypertension was conducted by using a stratified multistage random sampling strategy, with participants aged 21 to 72 years.