Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Survival following transarterial chemoembolisation (TACE) for hepatocellular cancer (HCC) is variable. We explored targeted sequencing of circulating tumour DNA (ctDNA) as a prognostic biomarker. Plasma samples (n = 97) were collected at baseline and following TACE. Targeted, ultra-deep sequencing was conducted on 18 somatic mutations related to the molecular pathogenesis of HCC. Median progression-free survival and overall survival were 11.6 months (95% CI: 5.83-21.2) and 34 months (95% CI: 22.35-45.60), respectively. CTNNB1 and ARID1A were the most frequently mutated genes, present in 25% of baseline circulating samples, followed by SF3B1 (20%) and TERT (18%). The presence of mutations in CTNNB1, TP53 ARID1A, and KEAP1 predicted for poor OS on univariable analysis. Findings suggest that ctDNA profiling of known genetic drivers of HCC may serve as a valuable prognostic biomarker prior to TACE and may assist with the stratification of patients following further evaluation in larger studies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218101 | PMC |
| http://dx.doi.org/10.1038/s41698-025-00961-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genomic characterization of novel bat kobuviruses in Madagascar: Implications for viral evolution and zoonotic risk.
PLoS One
September 2025
Department of Ecology and Evolution, University of Chicago, Illinois, United States of America.
Kobuviruses (family Picornaviridae, genus Kobuvirus) are enteric viruses that infect a wide range of both human and animal hosts. Much of the evolutionary history of kobuviruses remains elusive, largely due to limited screening in wildlife. Bats have been implicated as major sources of virulent zoonoses, including coronaviruses, henipaviruses, lyssaviruses, and filoviruses, though much of the bat virome still remains uncharacterized.
View Article and Find Full Text PDFPembrolizumab treatment in SMARCA4-deficient nonsmall cell lung cancer: high tumor mutational burden and programmed death-ligand 1(+) expression on circulating tumor cells for real-time monitoring: a case report.
Anticancer Drugs
September 2025
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Nonsmall cell lung cancer (NSCLC) with SMARCA4 deficiency represents a rare subset of lung tumors characterized by early metastasis, poor response to chemotherapy, and unfavorable prognosis. Established therapy strategies for SMARCA4-deficient NSCLC remain elusive. While immune checkpoint inhibitors have been proposed as a potential solution, their efficacy remains uncertain.
View Article and Find Full Text PDFSystemic Delivery of an mRNA-Encoding, Tumor-Activated Interleukin-12 Lock to Eliminate Tumors and Avoid Immune-Related Adverse Events.
Nano Lett
September 2025
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.
Interleukin-12 (IL-12) is a robust proinflammatory cytokine that activates immune cells, such as T cells and natural killer cells, to induce antitumor immunity. However, the clinical application of recombinant IL-12 has been limited by systemic immune-related adverse events (irAEs) and rapid degradation. To address these challenges, we employed mRNA technology to encode a tumor-activated IL-12 "lock" fusion protein that offers both therapeutic efficacy and systemic safety.
View Article and Find Full Text PDFStability of microRNAs in serum and plasma reveal promise as a circulating biomarker.
Noncoding RNA Res
December 2025
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
Purpose: To verify the stability and reliability of circulating microRNA (miRNA) profiles in plasma and serum under different processing and storage conditions to inform future applications to circulating biomarker analyses.
Background: The development of blood-based methods for early disease detection has become increasingly desirable across various medical fields. RNA profiles have been investigated but have been a challenge due to rapid degradation of the analyte by ubiquitous RNases.
Avian reovirus in Italy: three episodes of abnormal losses in offspring of vaccinated broiler breeders.
Vet Ital
September 2025
Istituto Zooprofilattico Sperimentale delle Venezie.
Avian reovirus (ARV) is an important pathogen of poultry and the causative agent of viral arthritis/tenosynovitis. The disease can cause severe clinical signs in broiler flocks at an early age, resulting in major welfare issues and substantial economic losses for the poultry industry. Vaccination of breeders is widely used to control the disease, aiming to reduce vertical transmission and provide maternal antibodies to offspring.
View Article and Find Full Text PDF