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A strong geomagnetic storm that occurred on 01-December-2023 triggered unusual equatorial plasma bubbles (EPB) over 100-140°E longitudes, which persisted for several hours after sunrise on the next day. FORMOSAT-7/COSMIC-2 and ground-based global navigation satellite system observations, and Global Ionospheric Specification (GIS) electron density are used to investigate this long-lasting unseasonal EPB episode in the solstice period over Asia-Pacific. The results show that in presence of elevated F-layer bottom-side aided by prompt penetration electric field (PPEF), large-scale traveling ionospheric disturbances (LSTID) generated by high-latitude Joule heating seeded the instability soon after sunset. However, it is a second phase of reinforced EPBs generated in the post-midnight period triggered by another group of larger LSTIDs that uncharacteristically prolonged into daytime hours. The GIS observations further provide evidence that the extremely low background ionization on the following day due to composition changes during the negative storm phase enabled these EPBs to survive even after sunrise before the depleted flux tubes were refilled by fresh ionization. The coordinated ground- and space-based observations demonstrate the causal links for the rare unseasonal EPBs occurring in the post-sunset and post-midnight periods over the same longitude sector and the latter persisting several hours after sunrise with potentially enduring space weather implications on satellite communication and navigation.
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http://dx.doi.org/10.1038/s41598-025-08791-9 | DOI Listing |
Mol Psychiatry
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Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Pharmacological modulation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) through dual GIP/GLP-1 receptor agonists, commonly used for diabetes and obesity, shows promise in reducing alcohol consumption. We applied drug-target Mendelian randomization (MR) using genetic variation at these loci to assess their long-term effects on problematic alcohol use (PAU), binge drinking, alcohol misuse classifications, liver health, and other substance use behaviors. Genetic proxies for lowered BMI, modeling the appetite-suppressing and weight-reducing effects of variants in both the GIPR and GLP1R loci ("GIPR/GLP1R"), were linked with reduced binge drinking in the primary (β = -0.
View Article and Find Full Text PDFGenome Res
September 2025
College of Life Science, Sichuan Agricultural University, Ya'an, 625014, People's Republic of China;
Poultry egg production is shaped by the intertwined action of multiple physiological systems, greatly magnifying the complexity of its underlying genetic regulation. Although multitissue mapping of regulatory variants offers a powerful route to untangle this complexity, comprehensive data sets in ducks remain scarce. Meanwhile, the contributions of peripheral systems beyond neuroendocrine regulation on poultry egg production are still largely unexplored.
View Article and Find Full Text PDFLife Sci Alliance
December 2025
Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA
Nε-lysine acetylation in the lumen of the ER requires two acetyltransferases, ATase1/NAT8B and ATase2/NAT8. They are type II membrane proteins and belong to the larger GNAT superfamily of acetyltransferases. Their enzymatic activity is tightly coupled to the import of acetyl-CoA in the lumen of the ER by AT-1/SLC33A1.
View Article and Find Full Text PDFJ Immunother Cancer
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Cellular Immunotherapy Program, Massachusetts General Hospital, Boston, Massachusetts, USA
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View Article and Find Full Text PDFJ Immunother Cancer
September 2025
Division of Hematology & Oncology, Department of Medicine, School of Medicine, University of California, Irvine, California, USA
Background: γδ T cells possess unique immunological features including tissue tropism, major histocompatibility complex-independent antigen recognition, and hybrid T/natural killer cell properties that make them promising candidates for cancer immunotherapy. However, the therapeutic potential of Vδ1 γδ T cells, particularly when engineered with chimeric antigen receptors (CARs), remains underexplored in solid tumors such as pancreatic cancer (PC), largely due to their low abundance in peripheral blood and challenges in ex vivo expansion. This study aims to directly compare the preclinical safety and efficacy among CAR-engineered Vδ1 γδ T cells, Vδ2 γδ T cells, and conventional αβ T cells.
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