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http://dx.doi.org/10.1007/s11686-025-01062-7 | DOI Listing |
Front Physiol
August 2025
Department of Anorectal Surgery, Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, China.
Background And Aims: Crohn's disease (CD) exhibits escalating incidence in China, particularly in coastal regions undergoing rapid industrialization. We aim to investigate the epidemiological characteristics of CD and identify factors influencing diagnostic delay in the Yancheng region of China.
Methods: A cross-sectional analysis was conducted on CD patients from two tertiary medical centers (Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine and Yancheng No.
Cancer Med
September 2025
Division of Clinical & Translational Cancer Research, Medical Sciences Campus, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico.
Background: Gastric cancer (GC) is the fourth leading cause of cancer-related death globally. Tumor profiling has revealed actionable gene alterations that guide treatment strategies and enhance survival. Among Hispanics living in Puerto Rico (PRH), GC ranks among the top 10 causes of cancer-related death.
View Article and Find Full Text PDFInt J Colorectal Dis
September 2025
Internal Medicine Department, Mirwais Regional Hospital, Kandahar, Afghanistan.
Background: The primary treatment for colorectal cancer, which is very prevalent, is surgery. Anastomotic leaking poses a significant risk following surgery. Intestinal perfusion can be objectively and instantly assessed with indocyanine green fluorescence imaging, which may lower leakage rates and enhance surgical results.
View Article and Find Full Text PDFJ Int Med Res
September 2025
Obstetrics and Gynecology Department, Wuhan University Zhongnan Hospital, China.
ObjectiveThis study aimed to evaluate the efficacy and safety of hyperthermic intraperitoneal intraoperative chemotherapy (HIPEC) in patients with advanced ovarian cancer.MethodsA total of 200 patients with advanced ovarian cancer were enrolled in this retrospective study and randomly allocated to two groups (research registry number: 11353). On the first day after abdominal closure, routine treatment was performed in the non-HIPEC group, whereas HIPEC was performed in the HIPEC group.
View Article and Find Full Text PDFBioorg Chem
September 2025
The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, North
The high prevalence and drug resistance of superficial fungal infections (SFIs) pose a serious global public health challenge, urgently necessitating the development of novel antifungal drugs with unique structures and novel targets. Evodiamine derivatives are promising antifungal drug leads, yet they suffer from suboptimal activity and unclear action mechanisms. In this study, a series of N(14)-phenyl evodiamine derivatives were designed, synthesized and tested for their biological activities.
View Article and Find Full Text PDF