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With the rapid development of big data and artificial intelligence, the demand for memory has exploded. As a key data structure in modern databases and distributed storage systems, the Log-Structured Merge Tree (LSM-tree) has been widely employed (such as LevelDB, RocksDB, etc.) in systems based on key-value pairs due to its efficient writing performance. In LSM-tree-based KV stores, typically deployed on systems with DRAM-SSD storage, the KV items are first organized into MemTable as buffer for SSTables in main memory. When the buffer size exceeds the threshold, MemTable is flushed to the SSD and reorganized into an SSTable, which is then passed down level by level through compaction. However, the compaction degrades write performance and SSD endurance due to significant write amplification. To address this issue, recent proposals have mostly focused on redesigning the structure of LSM trees. We discover the prevalence of unchanged data blocks (UDBs) in the LSM-tree compaction process, i.e., UDBs are written back to SSD the same as they are read into memory, which induces extra write amplification and degrades I/O performance. In this paper, we propose a KV store design in SSD, called RemapCom, to exploit remapping on these UDBs. RemapCom first identifies UDBs with a lightweight state machine integrated into the compaction merge process. In order to increase the ratio of UDBs, RemapCom further designs a UDB retention method to further develop the benefit of remapping. Moreover, we implement a prototype of RemapCom on LevelDB by providing two primitives for the remapping. Compared to the state of the art, the evaluation results demonstrate that RemapCom can reduce write amplification by up to 53% and improve write throughput by up to 30%.
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http://dx.doi.org/10.3390/mi16060699 | DOI Listing |
Talanta
September 2025
Department of Cardiology, Affiliated Huishan Hospital of Xinglin College, Nantong University, Wuxi Huishan District People's Hospital, Wuxi, 214187, China. Electronic address:
Disposable electrochemical aptasensors (DEAs) hold significant promise for different analyte detection across diverse fields, due to inherent advantages of rapid response, portability, low cost, and high sensitivity. This review systematically examines the design strategies, signal amplification methodologies, and recent advances in DEAs in the fields of environmental analysis, food safety monitoring, and medical diagnostics. Specifically, it critically evaluates construction strategies for screen-printed electrodes (SPEs) and paper-based electrodes, including substrate selection, ink formulations, and key fabrication techniques such as screen printing, inkjet printing, deposition methods, and direct-writing technologies.
View Article and Find Full Text PDFMol Diagn Ther
September 2025
Department of Clinical Oncology, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan.
Background: Recurrent gastric or gastroesophageal junction cancers have poor prognoses and limited treatment options. While archival tumor tissue is commonly used for genomic profiling, it may not reflect molecular changes at recurrence.
Objective: We aimed to assess the utility of a circulating tumor DNA analysis in identifying actionable genomic alterations at recurrence and compare findings with archival primary tumor profiles.
Cancers (Basel)
August 2025
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
High-risk neuroblastoma remains a major clinical challenge, with a five-year survival rate below 50% despite intensive multimodal therapies. MYCN amplification, a hallmark of high-risk disease, drives an aggressive transcriptional program that maintains undifferentiated and proliferative states in neuroblastoma cells. Given its central role in oncogenic transcription, MYCN represents an attractive therapeutic target; however, its undruggable nature has prompted efforts to identify upstream regulators or cofactors that sustain MYCN expression and oncogenic function.
View Article and Find Full Text PDFPharmaceutics
July 2025
Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, SI-1000 Ljubljana, Slovenia.
: Nanoparticles (NPs) were previously explored as enhancers in electroporation due to their potential to locally amplify electric fields near cell membranes, with gold nanoparticles (AuNPs) in particular showing promise in improving membrane permeability and gene electrotransfer (GET). In this study, we systematically investigated the influence of NP properties-including size, shape, surface functionalization, and material-on electroporation efficacy. : A combined approach using theoretical modeling and experimental validation was employed, encompassing numerical simulations, membrane permeabilization assays, transmission electron microscopy, and GET efficiency measurements.
View Article and Find Full Text PDFGenes (Basel)
July 2025
Laboratory of Human Genomics, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania.
: Miscarriage is an increasingly common event worldwide arising from various factors, and identifying its etiology is important for planning and managing any future pregnancies. It is estimated that about half of early pregnancy loss cases are caused by genetic abnormalities, while a significantly lower rate is found in late pregnancy loss. Multiplex ligation-dependent probe amplification (MLPA) can detect small changes within a gene with precise breakpoints at the level of a single exon.
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