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Introduction: Pediatric diabetes educators (PDEs) are scarce in low-resource settings (LRSs), compromising diabetes care and increasing morbidity and mortality.
Methods: The Indian Society for Pediatric & Adolescent Endocrinology (ISPAE) developed ISPAE Diabetes Education And Learning (IDEAL), a 12-week virtual program with 24 interactive sessions of 2 h each, 58 faculty members, practical assignments, a rigorous exit exam, and ongoing post-certification engagement via WhatsApp.
Results: Since October 2021, 177 PDEs (128 nonphysicians, 49 physicians) have been trained in 8 batches, 9th batch completing. Teaching is in English, but assignments are accepted in 8 Indian languages. A total of 91% of trainees were women, 24% were persons with type 1 diabetes or their parents, and 50% were from smaller cities. Engagement was high, with a 91% attendance rate. Post-session test scores improved significantly (p < 0.05). IDEAL received the ISPAD Innovation Award (2023) and ISPAD endorsement. Eighty-five of the 177 IDEAL alumni ("IDEALites") completed a post-course survey. Of these, 88% are actively contributing to pediatric diabetes care and earning recognition and awards for their efforts.
Challenges: This study has the following limitations: limited hands-on experience, a demanding program, and language barriers.
Conclusion: IDEAL is a pioneering, structured, intensive, virtual, award-winning PDE training program. Being accessible and sustainable, it can serve as a practical model for other programs in LRS.
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http://dx.doi.org/10.1159/000547140 | DOI Listing |
Horm Res Paediatr
September 2025
Background: Neonatal diabetes mellitus (NDM) is a rare monogenic disorder, typically diagnosed within the first six months of life. While NDM is well-recognized globally, data from India regarding its clinical characteristics, treatment strategies, and long-term outcomes are scarce.
Objectives: To describe the molecular characterization, clinical phenotype and follow-up of children with NDM.
J Clin Invest
September 2025
Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Understanding the genetic causes of diseases affecting pancreatic β cells and neurons can give insights into pathways essential for both cell types. Microcephaly, epilepsy and diabetes syndrome (MEDS) is a congenital disorder with two known aetiological genes, IER3IP1 and YIPF5. Both genes encode proteins involved in endoplasmic reticulum (ER) to Golgi trafficking.
View Article and Find Full Text PDFJ Clin Invest
September 2025
Department of Cellular and Molecular Medicine, UCSD, La Jolla, United States of America.
3-O-sulfation of heparan sulfate (HS) is the key determinant for binding and activation of Antithrombin III (AT). This interaction is the basis of heparin treatment to prevent thrombotic events and excess coagulation. Antithrombin-binding HS (HSAT) is expressed in human tissues, but is thought to be expressed in the subendothelial space, mast cells, and follicular fluid.
View Article and Find Full Text PDFPediatr Nephrol
September 2025
Pediatric Nephrology Department, Biobizkaia Health Research Institute, Cruces University Hospital, Barakaldo, Spain.
Copeptin, a stable glycopeptide derived from the precursor of arginine vasopressin (AVP), has emerged as a valuable surrogate biomarker for AVP due to its stability and ease of measurement. This narrative review explores the physiological role of copeptin, its utility as a diagnostic and prognostic biomarker in different kidney diseases, and its clinical relevance in renal tubular disorders. The clinical application of copeptin as a diagnostic biomarker is best established in the differential diagnosis of polyuria-polydipsia syndrome (PPS), distinguishing nephrogenic diabetes insipidus (NDI) from central diabetes insipidus (CDI) and primary polydipsia (PP).
View Article and Find Full Text PDFPediatr Ann
September 2025
Department of Pediatrics, George Washington University, Washington, DC and.
Routine growth monitoring includes plotting children on World Health Organization or Centers for Disease Control and Prevention charts that have primarily been developed on typical, healthy populations. However, it is advisable to plot children with known genetic conditions on specialized growth curves (SGCs) when they are available. In this review, we highlight the most common genetic conditions for which SGCs are available, clinical reasons to use SGCs based on specific rare diseases, and how these SGCs can be found.
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