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Defecatory dysfunction (DD) is a common cause of chronic constipation resulting from functional abnormalities or structural pelvic pathologies. Accurate diagnosis requires combining anorectal manometry (ARM), balloon expulsion test (BET), and defecography. This study evaluates the diagnostic utility of these modalities and explores uncertainties in their performance and interpretation. This retrospective study included 325 adult patients assessed for DD between 2020 and 2023. All patients went through ARM, BET in the left lateral position, and defecography. Statistical associations between test outcomes were analyzed to assess diagnostic concordance and significance. A strong correlation was observed between ARM and defecography, with 65% of patients with normal anal relaxation on ARM achieving normal rectal evacuation on defecography ( < 0.0001). Conversely, patients with paradoxical contraction during ARM demonstrated a higher likelihood of evacuation failure. BET demonstrated high specificity but limited sensitivity in association with relaxation on ARM and evacuation on defecography. BET failure did not demonstrate a significant association with the presence of pelvic floor pathologies. Combining ARM, BET, and defecography provides a comprehensive framework for diagnosing DD, addressing its functional and structural components. This integrated approach facilitates targeted interventions, ultimately improving clinical outcomes. This study demonstrates that anal relaxation on anorectal manometry significantly correlates with rectal evacuation on defecography, supporting its physiological relevance. Balloon expulsion in the left lateral position shows high specificity but low sensitivity for defecatory dysfunction. Notably, balloon expulsion test (BET) failure was not associated with anatomical abnormalities. An integrated diagnostic approach using anorectal manometry (ARM), BET, and defecography enhances accuracy in distinguishing functional from structural causes of pelvic floor dysfunction.
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http://dx.doi.org/10.1152/ajpgi.00100.2025 | DOI Listing |
Bioelectron Med
September 2025
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Unlabelled: Cervical spinal cord injury (SCI) impairs sensorimotor and autonomic functions. We investigated the effects of lumbosacral transcutaneous spinal cord stimulation (tSCS) on urinary bladder, bowel, and sexual function as well as cardiovascular and sensorimotor functions in one individual with chronic clinically motor-complete cervical SCI, 11 years post-injury. Following 30 sessions of lumbosacral tSCS, the individual presented with improved urinary bladder compliance as well as anorectal function in parallel with mitigation of the severity of autonomic dysreflexia during filling cystometry and anorectal manometry.
View Article and Find Full Text PDFAnn Med Surg (Lond)
September 2025
Department of General Surgery, Yangpu Hospital, Tongji University School of Medcine, Shanghai, China.
Introduction And Importance: For patients with locally advanced low rectal cancer (LARC) unresponsive to neoadjuvant chemoradiotherapy, achieving functional sphincter preservation remains a major challenge due to tumor invasiveness and complex anal reconstruction requirements.
Case Presentation: A 67-year-old female with LARC underwent extended radical resection involving anal sphincter/puborectalis muscle excision and partial vaginal wall resection. Anal reconstruction was performed via a free left gracilis myocutaneous flap routed in a "γ-shaped" configuration.
Pediatr Surg Int
August 2025
Department of Proctology, Longhua Hospital affiliated to Shanghai University of TCM, No.725 South Wanping Road, Shanghai, 200032, People's Republic of China.
Background: The current study aims to comprehensively evaluate the surgical impact on anal function in pediatric patients with anal fistulas, incorporating anorectal manometry, histopathological examination, and various rating scales.
Methods: The study focuses on infants and toddlers diagnosed with anal fistulas who underwent surgical intervention at Longhua Hospital, Shanghai University of Traditional Chinese Medicine, between November 2020 and January 2024. The participants were divided into two age cohorts: infants (0-12 months) and toddlers (13-36 months).
Neurogastroenterol Motil
August 2025
Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Introduction: Upper and lower gastrointestinal (GI) dysfunctions frequently coexist, potentially mediated by gastrocolonic or cologastric neural reflexes. This study aims to assess the prevalence of impaired gastric accommodation (GA) and delayed gastric emptying (GE) among patients with slow colonic transit (CT), dyssynergic defecation (DD), and to evaluate relationships between CT or DD with impaired GA and delayed GE.
Methods: We reviewed records of 178 adult patients at Mayo Clinic (2005-2025) with documented slow CT or DD (respectively based on scintigraphy and high-resolution anorectal manometry [ARM] and balloon expulsion [BE]) who underwent Tc-SPECT measurement of GA and scintigraphic GE of 320-kcal, 30% fat egg meal.
North Clin Istanb
February 2025
Department of Pediatric Surgery, Istanbul Medeniyet University Faculty of Medicine, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkiye.
Objective: An experience regarding full-thickness rectal biopsies (FTRB) indications and results is presented.
Methods: The records of patients who underwent FTRB between January 2010 and January 2022 were retrospectively reviewed.
Results: 107 patients were included.