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Background: The prevalence of somatic symptom and related disorders (SSRDs) in the neuroimmunology clinic is unknown.
Objective: To evaluate the prevalence and characteristics of SSRDs in patients referred to a tertiary neuroimmunology clinic.
Methods: We retrospectively evaluated the presence of SSRDs in patients referred to a tertiary neuroimmunology clinic from 2016 to 2023.
Results: 898 patients were referred; 204 (22.7 %) did not have a neuroimmunological disorder. Fifty-four patients (6.0 % of total; 26.5 % of non-neuroimmunological) were diagnosed with SSRDs (74 % females, average age 42.5, SD 10.9). Per the DSM5-TR criteria, the following categories were identified: functional neurological disorder (25 patients, 46.3 %), somatic symptom disorder (22 patients, 40.7 %), SSRD unspecified (4 patients, 7.4 %), and illness anxiety disorder (3 patients, 5.5 %). Forty-three patients (79.6 %) were referred for MS, and 10 (18.5 %) for autoimmune encephalitis. Twenty-two patients (40.7 %) were referred by general neurologists, 16 (29.6 %) were self-referrals, 12 (22.2 %) were referred by their primary care physicians, and 4 (7.4 %) were referred by other specialists. Eleven patients (20.4 %) were healthcare workers. Compared to MS patients evaluated at the same timeframe, SSRD patients were older, more likely to be white, and less likely to be black.
Conclusions: SSRDs are relatively common amongst patients referred to a neuroimmunology clinic without a neuroimmunological disorder. SSRD patients were older than MS patients and less likely to be black. Self-referral and working in healthcare were frequently seen among SSRD patients.
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http://dx.doi.org/10.1016/j.msard.2025.106588 | DOI Listing |
JCI Insight
September 2025
Edinburgh Medical School: Biomedical Sciences & Euan MacDonald Centre for M, University of Edinburgh, Edinburgh, United Kingdom.
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein. Several therapeutic approaches boosting SMN are approved for human patients, delivering remarkable improvements in lifespan and symptoms. However, emerging phenotypes, including neurodevelopmental comorbidities, are being reported in some treated SMA patients, indicative of alterations in brain development.
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September 2025
Division of Nephrology, Boston University Chobanian & Avedisian School of Medicine, Boston, United States of America.
Background: Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.
Methods: We conducted a phase 2, randomized, double-blind, multiple-dose, 3-arm clinical trial comparing oral calcifediol (25D), calcitriol (1,25D), and placebo among 150 critically ill adult patients at high-risk of moderate-to-severe AKI. The primary endpoint was a hierarchical composite of death, kidney replacement therapy (KRT), and kidney injury (baseline-adjusted mean change in serum creatinine), each assessed within 7 days following enrollment using a rank-based procedure.
Clin J Am Soc Nephrol
September 2025
University College London Great Ormond Street Hospital for Children and Institute of Child Health, London, UK.
Background: Experience with icodextrin use in children on long-term peritoneal dialysis is limited. We describe international icodextrin prescription practices and their impact on clinical outcomes: ultrafiltration, blood pressure control, residual kidney function (RKF), technique and patient survival.
Methods: We included patients under 21 years enrolled in the International Pediatric Peritoneal Dialysis Network (IPPN) between 2007 and 2024, on automated PD with a daytime dwell.
Kidney360
September 2025
Department of Pediatrics, Division of Pediatric Nephrology, Baylor College of Medicine, Houston, TX, United States.
Background: Dialysis in neonates with ESKD is often associated with multiple comorbidities and the need for more intensified dialysis regimens. With recent advances in prenatal interventions and infant specific KRT, survival of neonates with ESKD has improved over the last decade. Little is known however about the impact on the health care system of improved survival in this population.
View Article and Find Full Text PDFClin J Am Soc Nephrol
September 2025
Kidney Division, Peking University First Hospital, Peking University Institute of Nephrology; Key Laboratory of Kidney Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, China.
Background: The Therapeutic Effects of Steroids in IgA Nephropathy Global (TESTING) trial demonstrated that glucocorticoid therapy reduced proteinuria and improved kidney outcomes in patients with Immunoglobulin A Nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) plays a central role in IgAN pathogenesis by promoting immune complex formation. However, the effects of glucocorticoid on pathogenic IgA levels remain unclear.
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