Association of dietary spermidine intake with biological age acceleration and the mediating role of insulin-like growth factor 1 in the UK Biobank.

J Nutr Health Aging

State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, China. Electronic address:

Published: August 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402391PMC
http://dx.doi.org/10.1016/j.jnha.2025.100610DOI Listing

Publication Analysis

Top Keywords

association dietary
4
dietary spermidine
4
spermidine intake
4
intake biological
4
biological age
4
age acceleration
4
acceleration mediating
4
mediating role
4
role insulin-like
4
insulin-like growth
4

Similar Publications

Colorectal cancer ranks among the most prevalent and lethal malignant tumors globally. Historically, the incidence of colorectal cancer in China has been lower than that in developed European and American countries; however, recent trends indicate a rising incidence due to changes in dietary patterns and lifestyle. Lipids serve critical roles in human physiology, such as energy provision, cell membrane formation, signaling molecule function, and hormone synthesis.

View Article and Find Full Text PDF

Background: Bladder cancer represents a significant global health challenge, characterized by poorly understood risk factors. This study aims to synthesize meta-analytical evidence, quantify risk associations, and inform prevention strategies.

Methods: We conducted a comprehensive literature search in PubMed, Embase, Web of Science, and Cochrane Library up to October 2024.

View Article and Find Full Text PDF

Objective: To investigate the association between long-term glycemic control and cerebral infarction risk in patients with diabetes through a large-scale cohort study.

Methods: This prospective, community-based cohort study included 12,054 patients with diabetes. From 2006 to 2012, 38,272 fasting blood glucose (FBG) measurements were obtained from these participants.

View Article and Find Full Text PDF

Introduction: Night Eating Syndrome (NES) is a distinct psychopathological entity variously considered as a mental health disorder, eating disorder or circadian rhythm disorder. Medical students are faced with hectic schedules, sleep interruptions and high-stakes exams as they become healthcare providers. Such social factors coupled with poor dietary practices may impact their mental health and biological clocks, leading to NES amongst this population.

View Article and Find Full Text PDF

Consumption of mango has been associated with a number of beneficial effects on health which have been attributed to phenolic catabolites originating from (poly)phenols following ingestion. To investigate the origins of potentially bioactive phenolic catabolites, ileostomists and subjects with a full gastrointestinal tract on a low(poly)phenol diet ingested a mango pulp purée containing 426 μmol of (poly)phenols consisting mainly of gallotannins and cinnamic acids, along with 231 μmol of the aromatic amino acids phenylalanine and tyrosine. Over a 24 h period post-mango intake plasma and urine were collected and analysed by UHPLC-HRMS.

View Article and Find Full Text PDF